| 1 |
Course Introduction
Biomaterials Defined
Structural Hierarchy in Materials and Biology |
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| 2 |
Biomaterials Surfaces: Physics
Surface (vs. Bulk) Structure and Properties
Surface Energy
Adsorption, Segregation, and Reconstruction at Surfaces |
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| 3 |
Biomaterials Surfaces: Chemistry
Reactions at Surfaces: Chemisorption, Corrosion, Hydrolysis |
Problem set 1 out |
| 4 |
Biomaterials Surfaces: Chemistry (cont.) |
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| 5 |
Protein-Surface Interactions
Proteins: Structure, Properties, Functions
Protein Adsorption: Langmuir Model |
Problem set 1 due
Problem set 2 out |
| 6 |
Protein-Surface Interactions
Protein Adsorption: Complex Phenomena, Measurement |
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| 7 |
Cell-Surface Interactions: Host Response to Biomaterials
Cell Adhesion Mechanisms
Coagulation Cascade |
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| 8 |
Cell-Surface Interactions: Host Response to Biomaterials
Immune Response: Alternative Complement Activation |
Problem set 2 due
Problem set 3 out |
| 9 |
Surface Modification Methods Purposes
Plasma Treatments
Polymer/Organic Coatings
Patterned Surfaces |
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| 10 |
Surface Characterization in Vacuum
XPS/ESCA, AES, SIMS |
Problem set 3 due |
| 11 |
Quiz #1 |
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| 12 |
Surface Characterization in Situ (Aqueous Solution) Contact Angle, AFM |
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| 13 |
Quantifying Cell Behavior
Cell Cultures
Cellular Assays: Adhesion, Migration, Proliferation |
Problem set 4 out |
| 14 |
Quantifying Cell Behavior (cont.)
Cellular Assays: Differentiation, Function |
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| 15 |
Statistical Analysis
Error Sources, Distribution Functions, t- test, Fisher Test, Regression Methods |
Problem set 4 due
Problem set 5 out |
| 16 |
Biosensors and Diagnostic Devices
Biological Elements
Transduction Mechanisms
Properties
Examples: Fiber Optic Biosensors, Nanobarcodes |
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| 17 |
Drug Delivery: Controlled Release
Diffusion-controlled, Membrane-based and Osmotic Devices |
Problem set 5 due
Problem set 6 out |
| 18 |
Drug Delivery: Controlled Release (cont.)
Chemically-controlled Devices |
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| 19 |
Drug Delivery: Controlled Release (cont.)
Methods: Transdermal, Colloidal Vehicles
Mechanical Pumps |
Problem set 6 due |
| 20 |
Quiz #2 |
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| 21 |
Biomaterials for Organ Replacement
Organ Replacement Therapies
Mechanical Properties
Bone Substitutes |
Problem set 7 out |
| 22 |
Tissue Engineering
Cell Types
Approaches: In vitro, In vivo, Ex vivo/Cell Encapsulation
Scaffolds: Design and Fabrication |
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| 23 |
Tissue Engineering (cont.)
Case Examples: Artificial Pancreas, Cartilage, Nerve Regeneration |
Problem set 7 due |
| 24 |
Class Review and Evaluations |
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| 25 |
Final Exam |
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