Now showing items 1-5 of 5

    • Direct Recruitment of Polycomb Repressive Complex 1 to Chromatin by Core Binding Transcription Factors 

      Yu, Ming; Mazor, Tali; Huang, Hui; Huang, Hsuan-Ting; Kathrein, Katie L.; e.a. (Elsevier, 2012-02)
      Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study we show that ...
    • Extensive changes in DNA methylation are associated with expression of mutant huntingtin 

      Ng, Christopher W.; Yildirim, Ferah; Yap, Soon Ming Micha; Dalin, Simona Sara; Matthews, Bryan; e.a. (National Academy of Sciences (U.S.), 2013-01)
      The earliest stages of Huntington disease are marked by changes in gene expression that are caused in an indirect and poorly understood manner by polyglutamine expansions in the huntingtin (HTT) protein. To explore the ...
    • Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated Transcriptional Regulation by ETV3 

      Carlson, Scott M.; Chouinard, Candace R.; Labadorf, Adam; Lam, Carol J.; Schmelzle, Katrin; e.a. (American Association for the Advancement of Science (AAAS), 2011-10)
      The mitogen-activated protein kinase (MAPK) extracellular signal–regulated kinase 2 (ERK2) is ubiquitously expressed in mammalian tissues and is involved in a wide range of biological processes. Although MAPKs have been ...
    • Linking Proteomic and Transcriptional Data through the Interactome and Epigenome Reveals a Map of Oncogene-induced Signaling 

      Huang, Shao-shan Carol; Clarke, David C.; Gosline, Sara Jane Calafell; Labadorf, Adam; Chouinard, Candace R.; e.a. (Public Library of Science, 2013-02)
      Cellular signal transduction generally involves cascades of post-translational protein modifications that rapidly catalyze changes in protein-DNA interactions and gene expression. High-throughput measurements are improving ...
    • Targeting H3K4 trimethylation in Huntington disease 

      Ng, Christopher W.; Yildirim, Ferah; Gipson, Theresa Anne; Labadorf, Adam; Housman, David E.; e.a. (National Academy of Sciences (U.S.), 2013-08)
      Transcriptional dysregulation is an early feature of Huntington disease (HD). We observed gene-specific changes in histone H3 lysine 4 trimethylation (H3K4me3) at transcriptionally repressed promoters in R6/2 mouse and ...