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    • Negative Self-Regulation of TLR9 Signaling by Its N-Terminal Proteolytic Cleavage Product 

      Ploegh, Hidde; Lee, Sungwook; Kang, Dongju; Ra, Eun A.; Lee, Taeyun A.; e.a. (American Association of Immunologists, 2014-09)
      TLR signaling is essential to innate immunity against microbial invaders and must be tightly controlled. We have previously shown that TLR9 undergoes proteolytic cleavage processing by lysosomal proteases to generate two ...