Browsing by Author "Yaari, Gur"
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The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
Sok, Devin; Laserson, Uri; Laserson, Jonathan; Liu, Yi; Vigneault, Francois; e.a. (Public Library of Science, 2013-11)Broadly neutralizing HIV antibodies (bnAbs) are typically highly somatically mutated, raising doubts as to whether they can be elicited by vaccination. We used 454 sequencing and designed a novel phylogenetic method to ... -
High-resolution antibody dynamics of vaccine-induced immune responses
Laserson, Uri; Vigneault, Francois; Gadala-Maria, Daniel; Yaari, Gur; Uduman, Mohamed; e.a. (National Academy of Sciences (U.S.), 2014-03)The adaptive immune system confers protection by generating a diverse repertoire of antibody receptors that are rapidly expanded and contracted in response to specific targets. Next-generation DNA sequencing now provides ...