Browsing by Author "D'Andrea, Alan D."
Now showing items 1-2 of 2
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Proteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer
Cron, Kyle R.; Zhu, Kaya; Kushwaha, Deepa S.; Hsieh, Grace; Merzon, Dmitry; e.a. (Public Library of Science, 2013-09)Despite optimal radiation therapy (RT), chemotherapy and/or surgery, a majority of patients with locally advanced non-small cell lung cancer (NSCLC) fail treatment. To identify novel gene targets for improved tumor control, ... -
Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) κ, and Pol ζ
Wojtaszek, Jessica; Lee, Chul-Jin; D'Souza, Sanjay Victor; Minesinger, Brenda; Kim, Hyungjin; e.a. (American Society for Biochemistry and Molecular Biology (ASBMB), 2012-08)DNA synthesis across lesions during genomic replication requires concerted actions of specialized DNA polymerases in a potentially mutagenic process known as translesion synthesis. Current models suggest that translesion ...