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Now showing items 54343-54362 of 142661
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Genetic resistance to diet-induced obesity in chromosome substitution strains of mice
(Springer-Verlag, 2010-02)Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-Chr[superscript A/J]/NaJ panel of chromosome ... -
The Genetic Revolution Highlights the Importance of Nondiscriminatory and Comprehensive Health Insurance Coverage
(Informa UK Limited, 2019-09)Kenneth Arrow, the economist whose 1963 article established the principles of modern health economics, once posed a parable to show the pernicious role that information can play in insurance markets. Suppose there are two ... -
A genetic risk system for genetic counselors
(Massachusetts Institute of Technology, 1999) -
Genetic Screens in Human Cells Using the CRISPR-Cas9 System
(American Association for the Advancement of Science (AAAS), 2013-12)The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 system for genome editing has greatly expanded the toolbox for mammalian genetics, enabling the rapid generation of isogenic cell lines ... -
Genetic screens in vivo using the CRISPR/Cas9 system
(Massachusetts Institute of Technology, 2017)An unmet and paramount need in the field of cancer research is to rapidly translate basic biological findings to clinically relevant therapeutics for cancer patients. Recent technological advances have generated many ... -
Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility
(Springer Science and Business Media LLC, 2020)© 2020, The Author(s). Artemisinins have revolutionized the treatment of Plasmodium falciparum malaria; however, resistance threatens to undermine global control efforts. To broadly explore artemisinin susceptibility in ... -
Genetic Sensor for Strong Methylating Compounds
(American Chemical Society (ACS), 2013-09)Methylating chemicals are common in industry and agriculture and are often toxic, partly due to their propensity to methylate DNA. The Escherichia coli Ada protein detects methylating compounds by sensing aberrant methyl ... -
Genetic technologies to engineer and understand the microbiome
(Massachusetts Institute of Technology, 2018)The microbes that inhabit the human body are integral to human health and disease: from inflammatory bowel disease to allergy, metabolic syndrome to autism. Due to its high connectivity with human physiology, manipulation ... -
A genetic test of the role of activins in mouse mesoderm formation
(Massachusetts Institute of Technology, 1995) -
Genetic topography of brain morphology
(National Academy of Sciences (U.S.), 2013-10)Animal data show that cortical development is initially patterned by genetic gradients largely along three orthogonal axes. We previously reported differences in genetic influences on cortical surface area along an ... -
Genetic variants in the bipolar disorder risk locus SYNE1 that affect CPG2 expression and protein function
(Springer Science and Business Media LLC, 2019-01)Bipolar disorder (BD) is a common mood disorder characterized by recurrent episodes of mania and depression. Both genetic and environmental factors have been implicated in BD etiology, but the biological underpinnings ... -
Genetic Variation in Preferences for Giving and Risk Taking
(MIT Press, 2009-05)In this paper, we use the classical twin design to provide estimates of genetic and environmental influences on experimentally elicited preferences for risk and giving. Using standardmethods from behavior genetics, we ... -
Genetic, clinical and population priors for brain images
(Massachusetts Institute of Technology, 2016)We develop mathematical models that exploit external information to improve analysis of a medical scan. Medical images enable visualization of the human body, and are central in clinical practice and many large-scale ... -
The genetic, neuronal, and chemical basis for microbial discrimination in Caenorhabditis elegans
(Massachusetts Institute of Technology, 2016)Discrimination among pathogenic and beneficial microbes is essential for host organism immunity and homeostasis. Increasingly, the nervous system of animals is being recognized as an important site of bacterial recognition, ... -
Genetically encodable calcium sensors for Magnetic Resonance Imaging
(Massachusetts Institute of Technology, 2018)A key requirement for understanding the workings of the brain is to fill in the explanatory gap between molecular phenomena and identifiable behavior at the organismal level. Magnetic resonance imaging (MRI) provides a ... -
Genetically encoded calcium indicator with NTnC-like design and enhanced fluorescence contrast and kinetics
(BioMed Central, 2018-02)Background The recently developed genetically encoded calcium indicator (GECI), called NTnC, has a novel design with reduced size due to utilization of the troponin C (TnC) as a Ca²⁺-binding moiety inserted ... -
Genetically encoded molecular tools for light-driven silencing of targeted neurons [Chapter 3]
(Elsevier, 2012-02)The ability to silence, in a temporally precise fashion, the electrical activity of specific neurons embedded within intact brain tissue, is important for understanding the role that those neurons play in behaviors, brain ... -
A genetically encoded near-infrared fluorescent calcium ion indicator
(Springer Nature, 2019)© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. We report an intensiometric, near-infrared fluorescent, genetically encoded calcium ion (Ca2+) indicator (GECI) with excitation and emission ... -
A genetically encoded near-infrared fluorescent calcium ion indicator
(Springer Science and Business Media LLC, 2019-01)© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. We report an intensiometric, near-infrared fluorescent, genetically encoded calcium ion (Ca2+) indicator (GECI) with excitation and emission ...
