Browsing by Subject "B-lymphocytes, drug effects"

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    • Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes 

      Hu, Chih-Chi Andrew; Dougan, Stephanie K.; Winter, Sebastian Virreira; Paton, Adrienne W.; Paton, James C. (Rockefeller University Press, 2009-10)
      Shiga-toxigenic Escherichia coli (STEC) use subtilase cytotoxin (SubAB) to interfere with adaptive immunity. Its inhibition of immunoglobulin secretion is both rapid and profound. SubAB favors cleavage of the newly synthesized ...