http://hdl.handle.net/1721.1/33977 Biological Engineering (20) http://hdl.handle.net/1721.1/44634 2.782J / 3.961J / 20.451J / HST.524J Design of Medical Devices and Implants, Spring 2003 Yannas, Ioannis V. Spector, Myron Solution of clinical problems by use of implants and other medical devices. Systematic use of cell-matrix control volumes. The role of stress analysis in the design process. Anatomic fit: shape and size of implants. Selection of biomaterials. Instrumentation for surgical implantation procedures. Preclinical testing for safety and efficacy: risk/benefit ratio assessment. Evaluation of clinical performance: design of clinical trials. Project materials drawn from orthopedic devices, soft tissue implants, artificial organs, and dental implants. http://hdl.handle.net/1721.1/35718 20.462J / 3.962J Molecular Principles of Biomaterials (BE.462J), Spring 2003 Irvine, Darrell J. Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces. http://hdl.handle.net/1721.1/34966 3.051J / 20.340J Materials for Biomedical Applications, Spring 2004 Mayes, Anne M. Introduction to the interactions between cells and surfaces of biomaterials. Surface chemistry and physics of selected metals, polymers, and ceramics. Surface characterization methodology. Modification of biomaterials surfaces. Quantitative assays of cell behavior in culture. Biosensors and microarrays. Bulk properties of implants. Acute and chronic response to implanted biomaterials. Topics in biomimetics, drug delivery, and tissue engineering. Laboratory demonstrations.