http://hdl.handle.net/1721.1/33990 Health Sciences and Technology (HST) http://hdl.handle.net/1721.1/45560 HST.583 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis, Fall 2004 Gollub, Randy L. Savoy, Robert Wald, Lawrence Banzett, Robert B. Dickerson, Bradford C Melcher, Jennifer R. Kennedy, David N. (David Nelson), 1962- Tuch, David Solomon, 1973- Jovicich, Jorge Greve, Doug Mandeville, Joe Vangel, Mark Geoffrey Hoge, Rick Blood, Anne Hadjikhani, Nouchine Moore, Christopher Salat, David Sigalovsky, Irina S., 1972- Stufflebeam, Steven M Zalesky, Martin Provides information relevant to the conduct and interpretation of human brain mapping studies. Provides in-depth coverage of the physics of image formation, mechanisms of image contrast, and the physiological basis for image signals. Parenchymal and cerebrovascular neuroanatomy and application of sophisticated structural analysis algorithms for segmentation and registration of functional data are discussed. Additional topics include fMRI experimental design including block design, event related and exploratory data analysis methods, and building and applying statistical models for fMRI data. Human subject issues including informed consent, institutional review board requirements and safety in the high field environment are also presented. Probability, linear algebra, differential equations, and introductory or college-level subjects in neurobiology, physiology, and physics is required. http://hdl.handle.net/1721.1/44634 2.782J / 3.961J / 20.451J / HST.524J Design of Medical Devices and Implants, Spring 2003 Yannas, Ioannis V. Spector, Myron Solution of clinical problems by use of implants and other medical devices. Systematic use of cell-matrix control volumes. The role of stress analysis in the design process. Anatomic fit: shape and size of implants. Selection of biomaterials. Instrumentation for surgical implantation procedures. Preclinical testing for safety and efficacy: risk/benefit ratio assessment. Evaluation of clinical performance: design of clinical trials. Project materials drawn from orthopedic devices, soft tissue implants, artificial organs, and dental implants. http://hdl.handle.net/1721.1/41934 HST.921 / HST.923 Information Technology in the Health Care System of the Future, Spring 2003 Locke, Steven E. (Steven Elliot) Bergeron, Bryan P. Sands, Daniel Z. Blander, Jeffrey The healthcare system in the US has been in the midst of a rapid transition in response to changing trends and patterns of care. The growing emphasis on evidence-based medical practice, continuous quality improvement, clinical and cost-effectiveness, and risk management have led to a sea change in medical practice that has been stressful for clinicians, patients, and administrators. As care becomes more tightly managed, it becomes a challenge for clinicians, administrators, and patients to balance time, money, resources, and clinical outcomes. Can emerging technologies help solve these complex problems? How has the demise of the dot.com industry effected these trends and slowed the proliferation of potential solutions? This innovative, trans-faculty course will teach the student how information technologies are shaping and redefining the health care marketplace through examining aspects related to 1) improved economies of scale, 2) greater technical and business efficiencies in the delivery of care to patients, 3) advanced tools for patient education and self-care, 4) network integrated decision support tools for clinicians, and 5) e-health applications and e-commerce. Students are required to take this course in conjunction with HST 923, the tutorial/practicum portion of the course, where they will work in interdisciplinary teams (including students in medicine, business, law, engineering, computer science, media, public health, and government) to analyze, develop, and present an innovative solution to a current or future clinical management program or health care problem which will incorporate (but is not limited to) management techniques, services, and technologies as presented during lectures and laboratories. Students' proposed solutions will draw upon their understanding of tools and principles acquired during the course and will be presented as an application design on the final day of the course. Opportunities to interact with corporate sponsors will enhance the emphasis on practical solutions to real world problems.Sponsored driven projects in past years have included those from Pfizer Health Solutions, Merck, Johnson and Johnson, Mass General, and Warner Lambert. (Note: A special project will be organized and supported by the faculty this year to help students identify ways to support efforts to combat bio-terrorism through improved uses of clinical and bioinformatic systems.) http://hdl.handle.net/1721.1/36883 6.021J / 2.791J / 2.794J / 6.521J / BE.370J / BE.470J / HST.541J Quantitative Physiology: Cells and Tissues, Fall 2002 Freeman, Dennis M. Weiss, Thomas Fischer Poe, Mya Principles of mass transport and electrical signal generation for biological membranes, cells, and tissues. Mass transport through membranes: diffusion, osmosis, chemically mediated, and active transport. Electric properties of cells: ion transport; equilibrium, resting, and action potentials. Kinetic and molecular properties of single voltage-gated ion channels. Laboratory and computer exercises illustrate the concepts. For juniors and seniors. Students engage in extensive written and oral communication exercises. Meets with graduate subject 6.521J, but assignments differ.