http://hdl.handle.net/1721.1/7795 http://hdl.handle.net/1721.1/49754 Oxygen-oxygen bonds : catalytic redox pathways in energy storage Fried, Stephen D. (Stephen David), 1987- Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2009. Vita. Includes bibliographical references. http://hdl.handle.net/1721.1/49617 The heat of fusion of iodine and the use of liquid iodine as a solvent in determining molecular weights Barnard, Kenneth H Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1912. MIT copy bound with: Analysis of gas blacks / Frank D. Bishop -- Identification of certain coal tar dyes used in coloring foods / Hattie D. F. Haub -- A rapid volumetric method for tan analysis / M. W. Hedden -- A study of the so-called false equilibrium between selenium and hydrogen / Walter H. J. Taylor -- An investigation of methods recently proposed for the determination of tin in canned food products / E. B. Wettengel. http://hdl.handle.net/1721.1/49600 Reactions of acetylene and its derivatives with aldehydes and ketones Blackman, Joseph Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1940. MIT copy bound with: Fractional separation of the rare earths by means of the organo-molecular compounds of the anhydrous halides / Arnold Arch. 1940. Includes bibliographical references (leaf 26). http://hdl.handle.net/1721.1/36279 Synthetic strategies to improve the cytotoxicity of platinum-based cancer therapeutics Saouma, Caroline Thalia The purpose of this thesis is to explore the conjugation of biomolecules to platinum(IV) compounds. Ever since the serendipitous discovery that cisplatin has cytotoxic properties in the 1970's, research has focused on both understanding the mode of action and making new potential drugs that have more desirable properties than cisplatin. Oxidizing cisplatin to platinum(IV) allows for the tethering of amines that can be used to target cancer cells. The first chapter is a brief introduction on the scope of platinum compounds that have been made. It also provides general background on the proposed mode of action. The second chapter adapts the knowledge of making cisplatin derived platinum(IV) complexes that are able to conjugate biomolecules, and adapts it to a second generation platinum drug, carboplatin. Furthermore, a method to make mono- or bis- substituted conjugates is devised. Chapter three describes the tethering of a series of estrogen linkers to oxidized derivatives of carboplatin, in hopes of seeing increased toxicity in ER(+) cells. This work mimics previous work in our lab which dealt with the tethering of estrogen to oxidized derivatives of cisplatin. Finally, in chapter four platinum-folate conjugates are described. Because cancer cells grossly overexpress folate receptors, tethering folic acid to platinum(IV) is desirable as it will allow for increased uptake in cancer cells. Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005. This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections. Includes bibliographical references (p. 73-75).