Transcriptional Regulation and Its Misregulation in Disease
Author(s)
Lee, Tong Ihn; Young, Richard A.; Young, Richard A.
DownloadYoung_Transcriptional regulation.pdf (1.312Mb)
PUBLISHER_CC
Publisher with Creative Commons License
Creative Commons Attribution
Terms of use
Metadata
Show full item recordAbstract
The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease.
Description
Available in PMC 2014 March 14.
Date issued
2013-03Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical ResearchJournal
Cell
Publisher
Elsevier
Citation
Lee, Tong Ihn, and Richard A. Young. "Transcriptional Regulation and Its Misregulation in Disease." Cell 152:6 (March 2013), pp. 1237-1251.
Version: Author's final manuscript
ISSN
00928674