Transcriptional Regulation and Its Misregulation in Disease
Name
Young_Transcriptional regulation.pdf
Size
1.31 MB
Format
Adobe PDF
Checksum (MD5)
3a8b29ca894b32aaa11daca30d7e8a7c
Author(s)
Lee, Tong Ihn
Young, Richard A.
Young, Richard A.
Date Issued
March 2013
Journal
Cell
Publisher
Elsevier
Citation
Lee, Tong Ihn, and Richard A. Young. "Transcriptional Regulation and Its Misregulation in Disease." Cell 152:6 (March 2013), pp. 1237-1251.
Version
Author's final manuscript
Abstract
The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease.
Description
Available in PMC 2014 March 14.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cell.2013.02.014
