Imprinting meets genomics: new insights and new challenges
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Pignatta_COPB_2012_revised[1].pdf
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585.73 KB
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Author(s)
Pignatta, Daniela
Gehring, Mary
Date Issued
September 2012
Journal
Current Opinion in Plant Biology
Publisher
Elsevier
Citation
Pignatta, Daniela, and Mary Gehring. “Imprinting Meets Genomics: New Insights and New Challenges.” Current Opinion in Plant Biology 15, no. 5 (November 2012): 530–535.
Version
Author's final manuscript
Abstract
Until recently, only a handful of imprinted genes, or genes with parent-of-origin dependent expression patterns, were known in plants. Study of these genes yielded key insights into mechanisms of monoallelic expression and imprinted gene function. The recent application of high throughput sequencing to the study of imprinting has confirmed that many previous findings are relevant on a genome-wide scale. The catalogue of imprinted genes in monocots and dicots now includes a large number of transcription factors, chromatin related genes, and metabolic or hormone biosynthesis enzymes. Interpretation of allele specific expression data remains a challenge, with careful validation of candidate imprinted genes necessary.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.pbi.2012.09.004
