Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model
Author(s)
Wood, Joseph; Wang, Ying-Ying; Zeng, Qi; Simons, Brian W; Fu, Jie; Chuang, Chi-Mu; Lai, Samuel K; Wu, T.-C.; Hung, Chien-Fu; Hanes, Justin; Simons, Brian W.; Lai, Samuel K.; Tang, Benjamin C.; Yang, Ming, S.M. Massachusetts Institute of Technology; Yu, Tao, Ph. D. Massachusetts Institute of Technology; ... Show more Show less
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Intraperitoneal (IP) chemotherapy is more effective than systemic chemotherapy for treating advanced ovarian cancer, but is typically associated with severe complications due to high dose, frequent administration schedule, and use of non-biocompatible excipients/delivery vehicles. Here, we developed paclitaxel (PTX)-loaded microspheres composed of di-block copolymers of poly(ethylene glycol) and poly(sebacic acid) (PEG-PSA) for safe and sustained IP chemotherapy. PEG-PSA microspheres provided efficient loading (∼13 % w/w) and prolonged release (∼13 days) of PTX. In a murine ovarian cancer model, a single dose of IP PTX/PEG-PSA particles effectively suppressed tumor growth for more than 40 days and extended the median survival time to 75 days compared to treatments with Taxol® (47 days) or IP placebo particles (34 days). IP PTX/PEG-PSA was well tolerated with only minimal to mild inflammation. Our findings support PTX/PEG-PSA microspheres as a promising drug delivery platform for IP therapy of ovarian cancer and potentially other metastatic peritoneal cancers.
Date issued
2014-01Department
Koch Institute for Integrative Cancer Research at MITJournal
Drug Delivery and Translational Research
Publisher
Springer US
Citation
Yang, Ming et al. “Intraperitoneal Delivery of Paclitaxel by Poly(ether-Anhydride) Microspheres Effectively Suppresses Tumor Growth in a Murine Metastatic Ovarian Cancer Model.” Drug Delivery and Translational Research 4.2 (2014): 203–209.
Version: Author's final manuscript
ISSN
2190-393X
2190-3948