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dc.contributor.authorChoi, Yoon Jong
dc.contributor.authorSaez, Borja
dc.contributor.authorAnders, Lars
dc.contributor.authorHydbring, Per
dc.contributor.authorStefano, Joanna
dc.contributor.authorBacon, Nickolas A.
dc.contributor.authorCook, Colleen
dc.contributor.authorKalaszczynska, Ilona
dc.contributor.authorSignoretti, Sabina
dc.contributor.authorScadden, David T.
dc.contributor.authorSicinski, Piotr
dc.contributor.authorYoung, Richard A
dc.date.accessioned2017-01-10T15:53:02Z
dc.date.available2017-01-10T15:53:02Z
dc.date.issued2014-06
dc.date.submitted2014-03
dc.identifier.issn1534-5807
dc.identifier.issn1878-1551
dc.identifier.urihttp://hdl.handle.net/1721.1/106321
dc.description.abstractD-type cyclins (D1, D2, and D3) are components of the mammalian core cell-cycle machinery and function to drive cell proliferation. Here, we report that D-cyclins perform a rate-limiting antiapoptotic function in vivo. We found that acute shutdown of all three D-cyclins in bone marrow of adult mice resulted in massive apoptosis of all hematopoietic cell types. We demonstrate that adult hematopoietic stem cells are particularly dependent on D-cyclins for survival and that they are especially sensitive to cyclin D loss. Surprisingly, we found that the antiapoptotic function of D-cyclins also operates in quiescent hematopoietic stem and progenitor cells. Our analyses revealed that D-cyclins repress the expression of the death receptor Fas and its ligand, FasL. Acute ablation of D-cyclins upregulated these proapoptotic genes and led to Fas- and caspase 8-dependent apoptosis. These results reveal an unexpected function of cell-cycle proteins in controlling apoptosis in normal cell homeostasis.en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.devcel.2014.06.015en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleD-Cyclins Repress Apoptosis in Hematopoietic Cells by Controlling Death Receptor Fas and Its Ligand FasLen_US
dc.typeArticleen_US
dc.identifier.citationChoi, Yoon Jong et al. “D-Cyclins Repress Apoptosis in Hematopoietic Cells by Controlling Death Receptor Fas and Its Ligand FasL.” Developmental Cell 30.3 (2014): 255–267.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorYoung, Richard A
dc.relation.journalDevelopmental Cellen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsChoi, Yoon Jong; Saez, Borja; Anders, Lars; Hydbring, Per; Stefano, Joanna; Bacon, Nickolas A.; Cook, Colleen; Kalaszczynska, Ilona; Signoretti, Sabina; Young, Richard A.; Scadden, David T.; Sicinski, Piotren_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-8855-8647
mit.licensePUBLISHER_CCen_US


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