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SYK kinase mediates brown fat differentiation and activation

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dc.contributor.author Knoll, Marko
dc.contributor.author Winther, Sally
dc.contributor.author Natarajan, Anirudh
dc.contributor.author Yang, Huan
dc.contributor.author Jiang, Mengxi
dc.contributor.author Thiru, Prathapan
dc.contributor.author Shahsafaei, Aliakbar
dc.contributor.author Chavarria, Tony E.
dc.contributor.author Lamming, Dudley W.
dc.contributor.author Sun, Lei
dc.contributor.author Hansen, Jacob B.
dc.contributor.author Lodish, Harvey F
dc.date.accessioned 2018-02-13T14:39:49Z
dc.date.available 2018-02-13T14:39:49Z
dc.date.issued 2017-12
dc.date.submitted 2017-03
dc.identifier.issn 2041-1723
dc.identifier.uri http://hdl.handle.net/1721.1/113618
dc.description.abstract Brown adipose tissue (BAT) metabolism influences glucose homeostasis and metabolic health in mice and humans. Sympathetic stimulation of β-adrenergic receptors in response to cold induces proliferation, differentiation, and UCP1 expression in pre-adipocytes and mature brown adipocytes. Here we show that spleen tyrosine kinase (SYK) is upregulated during brown adipocyte differentiation and activated by β-adrenergic stimulation. Deletion or inhibition of SYK, a kinase known for its essential roles in the immune system, blocks brown and white pre-adipocyte proliferation and differentiation in vitro, and results in diminished expression of Ucp1 and other genes regulating brown adipocyte function in response to β-adrenergic stimulation. Adipocyte-specific SYK deletion in mice reduces BAT mass and BAT that developed consisted of SYK-expressing brown adipocytes that had escaped homozygous Syk deletion. SYK inhibition in vivo represses β-agonist-induced thermogenesis and oxygen consumption. These results establish SYK as an essential mediator of brown fat formation and function. en_US
dc.publisher Nature Publishing Group en_US
dc.relation.isversionof http://dx.doi.org/10.1038/s41467-017-02162-3 en_US
dc.rights Creative Commons Attribution 4.0 International License en_US
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en_US
dc.title SYK kinase mediates brown fat differentiation and activation en_US
dc.type Article en_US
dc.identifier.citation Knoll, Marko et al. “SYK Kinase Mediates Brown Fat Differentiation and Activation.” Nature Communications 8, 1 (December 2017) © 2017 The Author(s) en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Biology en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Biological Engineering en_US
dc.contributor.mitauthor Lodish, Harvey F
dc.relation.journal Nature Communications en_US
dc.identifier.mitlicense PUBLISHER_POLICY en_US
dc.eprint.version Final published version en_US
dc.type.uri http://purl.org/eprint/type/JournalArticle en_US
eprint.status http://purl.org/eprint/status/PeerReviewed en_US
dc.date.updated 2018-02-09T15:51:37Z
dspace.orderedauthors Knoll, Marko; Winther, Sally; Natarajan, Anirudh; Yang, Huan; Jiang, Mengxi; Thiru, Prathapan; Shahsafaei, Aliakbar; Chavarria, Tony E.; Lamming, Dudley W.; Sun, Lei; Hansen, Jacob B.; Lodish, Harvey F. en_US
dspace.embargo.terms N en_US
dc.identifier.orcid https://orcid.org/0000-0002-7029-7415


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