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Synthesis and reactivity studies of mono-, bi-, and trimetallic complexes supported by oxidatively-resistant polyanionic ligands
(Massachusetts Institute of Technology, 2017)
Investigations of the oxidatively-resistant hexacarboxamide cryptand, mBDCA-5t-H₆, to support mono-, bi-, and trimetallic complexes are presented. Selective single metal ion insertion into the cryptand was achieved to ...
Molecular design for controlling morphology in organic electronics
(Massachusetts Institute of Technology, 2018)
Chapter 1 gives an introduction to the structure, operation mechanism, performance parameters, and challenges of organic photovoltaic devices. We also discuss some strategies to improve the performance of photovoltaics, ...
Two-dimensional infrared spectroscopy of nucleic acids : application to tautomerism and DNA aptamer unfolding dynamics
(Massachusetts Institute of Technology, 2014)
The structural dynamics of nucleic acids are intimately related to their biological functions; however, our ability to study these molecular dynamics has been largely impeded by the lack of techniques that possess both ...
Cargo delivery into gram-negative bacteria via enterobactin uptake machinery
(Massachusetts Institute of Technology, 2014)
Chapter 1. Introduction to Iron Homeostasis and Siderophores Iron is an essential nutrient for almost all living organisms. This Chapter presents an overview of iron homeostasis in human and bacteria, as well as the biology ...
Elucidating the pumping mechanism of bacteriorhodopsin using dynamic nuclear polarization enhanced magic angle spinning NMR
(Massachusetts Institute of Technology, 2018)
Bacteriorhodopsin (bR) is comprised of 7 trans-membrane helices that enclose a retinylidene chromophore formed by a Schiff base (SB) between the retinal and Lys216. Due to bR's relative availability, it serves as a model ...
Molybdenum and tungsten alkylidene complexes for cis- and trans-selective ring-opening metathesis polymerization
(Massachusetts Institute of Technology, 2015)
Chapter 1 describes the synthesis of tert-butylimido alkylidene complexes for molybdenum and tungsten. A dimer species [chemical formula] served as a bisimido precursor. After alkylation with Grignard reagent, alkylidene ...
Kinetics and dynamics controlling proton-coupled electron transfer in ribonucleotide reductase
(Massachusetts Institute of Technology, 2015)
Proton-coupled electron transfer (PCET) reactions comprise a fundamental mechanism for energy transduction in nature. In catalyzing the conversion of ribonucleotides to deoxyribonucleotides, ribonucleotide reductase (RNR) ...
Synthesis of pyridines via [4 + 2] cycloadditions of vinylallenes with azadienophiles
(Massachusetts Institute of Technology, 2015)
Pyridines are an important class of heterocycle with widespread applications. However, the efficient preparation of substituted pyridines remains a challenge in organic synthesis. This thesis describes new annulation ...
Priming and processing glycosyltransferases in bacterial N-linked glycosylation pathways
(Massachusetts Institute of Technology, 2015)
Bacterial cell surfaces prominently feature a variety of complex glycoconjugates. Although these structures are very diverse, the biosynthesis of these glycoconjugates shares common themes. In particular, a priming ...
Optical transient grating measurements of micro/nanoscale thermal transport and mechanical properties
(Massachusetts Institute of Technology, 2015)
The laser-based transient grating technique was used to study phonon mediated thermal transport in bulk and nanostructured semiconductors and surface wave propagation in a monolayer of micron sized spheres. In the transient ...