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Sensitivity analysis for nonsmooth dynamic systems
(Massachusetts Institute of Technology, 2015)
Nonsmoothness in dynamic process models can hinder conventional methods for simulation, sensitivity analysis, and optimization, and can be introduced, for example, by transitions in flow regime or thermodynamic phase, or ...
Reachability and robust design in dynamic systems
(Massachusetts Institute of Technology, 2015)
Systems of engineering interest usually evolve in time. Models that capture this dynamic behavior can more accurately describe the system. Dynamic models are especially important in the chemical, oil and gas, and pharmaceutical ...
Photopolymerization-based signal amplification : mechanistic characterization and practical implementation
(Massachusetts Institute of Technology, 2015)
Polymerization-based signal amplification is an approach to biosensing that leverages the amplification inherent to radical polymerization to enhance signal associated with molecular recognition. This versatile technique ...
Dimensionality reduction in immunology : from viruses to cells
(Massachusetts Institute of Technology, 2015)
Developing successful prophylactic and therapeutic strategies against infections of RNA viruses like HIV requires a combined understanding of the evolutionary constraints of the virus, as well as of the immunologic ...
Studying self-entangled DNA at the single molecule level
(Massachusetts Institute of Technology, 2015)
Knots seem to be found every time one encounters long, stringy objects. At the macroscopic scale, knots are seen every day in shoelaces, tangled hair, or woven clothing, yet they also present themselves at the microscopic ...
Synthesis, nanostructure, and mechanics of thermoresponsively tough biomaterials from artificial polypeptides
(Massachusetts Institute of Technology, 2015)
Artificial protein hydrogels have attracted interest as injectable fillers and scaffolds for tissue engineering and regeneration, but the same features that enable minimally-invasive implantation of these biomaterials ...
Characterizing cell-cycle as a global regulator of stochastic transcription and noisy gene expression in S. cerevisiae
(Massachusetts Institute of Technology, 2014)
Even in the same environment, genetically identical cells can exhibit remarkable variability, or noise, in gene expression. This expression noise impacts the function of gene regulatory networks, depending on its origins. ...
Molecules to engines : combustion chemistry of alcohols and their application to advanced engines
(Massachusetts Institute of Technology, 2015)
A major challenge in energy is the identification of viable liquid fuels as alternatives to petroleum-based fuels. There are a wide variety of candidate fuels to select from and assessing each new fuel is far from trivial. ...
Particle tracking for understanding the properties and dynamics of bacterial biofilms
(Massachusetts Institute of Technology, 2015)
Bacterial biofilms consist of surface adherent bacteria that surround themselves with a polymer matrix which provides environmental protection and antibiotic resistance. Biofilms can grow on most implanted medical devices, ...
Controlling nanostructures of globular protein-polymer block copolymers in bulk solutions and in thin films
(Massachusetts Institute of Technology, 2016)
The self-assembly of globular protein-polymer diblock copolymers represents a promising technology for protein nanopatterning. The self-assembled materials have a high density of proteins and internal nanostructures that ...