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Robust genome editing with broad-targeting CRISPR enzymes
(Massachusetts Institute of Technology, 2020)
Programmable CRISPR enzymes are powerful and versatile tools for genome editing. They, however, require a specific protospacer adjacent motif (PAM) flanking the target site, which constrains the accessible sequence space ...
Polarization and toxicity in political discourse online
(Massachusetts Institute of Technology, 2020)
The web and social media promised to fundamentally change the public sphere by democratizing access to information and lowering barriers for participation in public discourse. While some of these expectations have been ...
Digital expressive media for supporting early literacy through child-driven, scaffolded play
(Massachusetts Institute of Technology, 2020)
Digital technology holds many promises for supporting early literacy development. To stimulate both l earning achievement and children's interest in literacy, i t i s beneficial f or a l earning activity to be playful, ...
Resynthesizing volumetric soundscapes : low-rank subspace methods for soundfield estimation and reconstruction
(Massachusetts Institute of Technology, 2020)
Sound and space are fundamentally intertwined, at both a physical and perceptual level. Sound radiates from vibrating materials, filling space and creating a continuous field through which a listener moves. Despite a long ...
Discrete mechanical metamaterials
(Massachusetts Institute of Technology, 2020)
Digital fabrication enables complex designs to be realized with improved speed, precision, and cost compared to manual techniques. Additive manufacturing, for example, is one of the leading methods for rapid prototyping ...
Olfactory interfaces : toward implicit human-computer interaction across the consciousness continuum
(Massachusetts Institute of Technology, 2020)
Human-computer interaction has traditionally focused on interfaces that provide explicit visual, auditory, or haptic feedback. This thesis proposes a new type of user interface that uses scent as an implicit, less conscious ...
Social and affective machine learning
(Massachusetts Institute of Technology, 2020)
Social learning is a crucial component of human intelligence, allowing us to rapidly adapt to new scenarios, learn new tasks, and communicate knowledge that can be built on by others. This dissertation argues that the ...
Autonomic activity from human videos
(Massachusetts Institute of Technology, 2020)
The autonomic nervous system (ANS) is a part of the nervous system that is responsible for regulation and integration of internal organs' functioning. Traditionally, for the assessment of the ANS function, autonomic activity ...
Self-aware self-assembly for space architecture : growth paradigms for in-space manufacturing
(Massachusetts Institute of Technology, 2020)
Humanity stands on the cusp of interplanetary civilization. As we prepare to venture into deep space, we face what appears to be an irreconcilable conundrum: at once a majestic domain for human exploration, while also a ...
Magnetomicrometry : tissue length tracking via implanted magnetic beads
(Massachusetts Institute of Technology, 2020)
Target tracking is necessary across a wide range of disciplines and scales, such as in monitoring tissues and cells, beam bending, fluid dynamics, human-computer interaction, and traffic. Due to these widespread applications, ...