Now showing items 1-5 of 5
The role of megakaryocytes and platelets in infection and immunothrombosis
(Massachusetts Institute of Technology, 2018)
Megakaryocytes (MKs), one of the largest and rarest hematopoietic stem cells in the bone marrow, have traditionally played a primary role in hemostasis as precursors to platelets, which are importantly, one of the most ...
Identification of reassortant influenza viruses at scale : algorithm and applications
(Massachusetts Institute of Technology, 2017)
Reassortment is a reticulate evolutionary process that results in genome shuffling; the most prominent virus known to reassort is the influenza A virus. Methods to identify reassortant influenza viruses do not scale well ...
Recognizing epigenetic patterns that mark the control of cell state in differentiation and disease
(Massachusetts Institute of Technology, 2015)
Unlike the genomic sequence, the epigenome is dynamic, responding to and influencing the cellular state. Understanding the ways in which chromatin structure exercises control over transcriptional programs during development ...
Principles for the design and construction of synthetic circuits utilizing protein-protein interactions in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 2016)
Within synthetic biology, significant progress in creating networks using transcriptional and translational control has been made, but a network comprised solely of protein-protein interactions has not yet been built. To ...
Epitranscriptomics : translational regulation of metabolism, drug resistance and proteostasis during cellular stress
(Massachusetts Institute of Technology, 2019)
The epitranscriptome -- the naturally occurring system of chemical modifications on ribonucleic acid (RNA) --