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Auto-tethering as a selection mechanism for recognition of multimeric substrates by the AAA+ unfoldase ClpX
(Massachusetts Institute of Technology, 2008)
The CIp/Hsp1OO enzymes, which belong to the AAA+ family of ATPases, use their unfoldase activity to degrade and remodel multimeric substrates in the bacterial cell. The mechanical energy exerted by CIp/Hsp1OO enzymes drives ...
Bioenergetics and metabolism of eukaryotic cell proliferation
(Massachusetts Institute of Technology, 2021)
Cellular growth and proliferation necessitates the transformation of cell-external nutrients into biomass. Strategies of biomass accumulation across the kingdoms of life are diverse and range from carbon fixation by ...