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Engineering translational multi-therapeutic targeted delivery vehicles for disease management
(Massachusetts Institute of Technology, 2015)
The complexity of growth, survival, and death signaling pathways in cancer continues to motivate extensive investigations using systems biology approaches to better inform treatments. Many of these drugs and drug combinations, ...
Microreactor technology : scale-up of multiphase continuous flow chemistries
(Massachusetts Institute of Technology, 2014)
Microreactors have been demonstrated to provide many advantages over conventional process technologies for the synthesis of chemical compounds and kinetic studies at the laboratory scale. High heat and mass transfer rates, ...
Nanoparticle systems that exploit host biology for diagnosis and treatment of disease
(Massachusetts Institute of Technology, 2014)
Over the past 30 years, advances in nanotechnology have generated a multitude of nanostructures exhibiting a breadth of physical, chemical, and biological properties that have tremendous potential to improve the detection ...
Methylated DNA detection using a high-affinity methyl-CpG binding protein and photopolymerization-based amplification
(Massachusetts Institute of Technology, 2015)
Methylation at the 5 position of the cytosine base, when followed by guanine (CpG) in the promoter region of a protein-coding gene, is an epigenetic modification that has been shown to be involved in gene silencing. While ...
Towards next-generation enzymatic generators of hydrogen peroxide in quantitative redox biology
(Massachusetts Institute of Technology, 2015)
Hydrogen peroxide (H₂O₂) is a natural byproduct of cellular metabolism that has also been implicated in numerous biological processes, including the respiratory burst, proliferation, apoptosis, and cellular signaling. H₂O₂ ...