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Solving for syntax
(Massachusetts Institute of Technology, 2021)
Among the key questions that have guided research into the nature of human language for the past sixty years, two have been particularly salient: (1) What constitutes knowledge of language? and (2) How is that knowledge ...
Programmable interfaces for biomedical and neuroscience applications
(Massachusetts Institute of Technology, 2021)
The rapidly changing fields of biomedical sciences and neuroscience increasingly adopt scientific and technological innovations to advance the diagnosis and treatment of disease. With the emergence of miniaturized and ...
Analytics for accelerating biomedical innovation
(Massachusetts Institute of Technology, 2021)
Despite the many breakthroughs in biomedical research and the increasing demand for new drugs to treat unmet medical needs, the productivity of research and development in the pharmaceutical industry has been steadily ...
Development of high-temperature firebrick resistance-heated energy storage (FIRES) using doped ceramic heating system
(Massachusetts Institute of Technology, 2021)
Towards combating climate change, the widespread replacement of fossil fuel energy with zero-carbon energy has two main requirements: (1) the ability to reach very high temperatures using zero-carbon energy to perform a ...
Structure and dynamics of influenza M2 proton channels from solid-state NMR
(Massachusetts Institute of Technology, 2021)
The A and B strains of influenza virus places a substantial burden on health, causing around 30 million illnesses, several hundred thousand hospitalizations, and a few tens of thousands of deaths every year in the United ...
Materials in extreme conditions : experimental developments and studies of systems far from equilibrium
(Massachusetts Institute of Technology, 2021)
Advances to shock wave generation and characterizations techniques are presented. Building upon previous work employing a novel quasi-2D focusing geometry, pressures of at least 100 GPa are achieved on the benchtop at the ...
Engineering exclusively-quadruplet codon translation in vivo
(Massachusetts Institute of Technology, 2021)
Living organisms universally encode amino acids with three-base codons specifying the twenty canonical amino acids. A genetic code entirely based on four-base codons would answer many questions about the origin of life and ...
Synthetic biology approaches for engineering bacteria as living therapeutics
(Massachusetts Institute of Technology, 2021)
Bacteria and humans have a long-standing symbiotic relationship. As the details of their symbiosis continue to be elucidated, it has become clear that these host-resident bacteria are much more than spectators within the ...
Phosphoproteomics analysis of Alzheimer's disease
(Massachusetts Institute of Technology, 2021)
Alzheimer's disease (AD) is a form of dementia characterized by the appearance of amyloid-[beta] plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Despite numerous clinical trials, a ...
CH-[pi] interactions play a central role in protein recognition of carbohydrates/
(Massachusetts Institute of Technology, 2021)
Carbohydrate-protein interactions play a central role in biology, but knowledge of the forces underlying them is limited. Carbohydrates are generally hydrophilic and therefore present unique challenges in their recognition. ...