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Now showing items 11-20 of 47
Phonon polariton interaction with patterned materials
(Massachusetts Institute of Technology, 2008)
The generation, propagation and detection of THz phonon polaritons are studied through both femtosecond pump-probe techniques, and Finite Difference Time Domain (FDTD) simulations in this thesis. The theory surrounding the ...
Recent advances in palladium-catalyzed carbon-carbon and carbon-boron bond forming processes
(Massachusetts Institute of Technology, 2008)
Chapter 1. Highly active and efficient catalyst systems derived from palladium precatalysts and monophosphine ligands for the Suzuki-Miyaura cross-coupling reaction of heteroaryl boronic acids and esters has been developed. ...
Progress in transition metal-based enantioselective catalysis
(Massachusetts Institute of Technology, 2008)
In Chapter 1, the first enantioselective cross-coupling reactions of racemic secondary benzylic halides are described (eq 1). This method was applied to the syntheses of intermediates employed by other groups in the ...
Structural studies of amyloid fibrils using solid-state NMR
(Massachusetts Institute of Technology, 2008)
he development of solid-state NMR techniques and application to amyloid fibrils are presented. In addition, a new method of selective inversion based on chemical shift anisotropy is presented. An improved method for highly ...
Molecular simulation of biomaterials and biomolecules at the solid-liquid interface
(Massachusetts Institute of Technology, 2008)
Biomaterials and biomineralization have been successfully utilized in a broad variety of technical applications. Properties of natural biopolymers, such as the ability to control the nucleation, growth, and organization ...
New reporters of protein trafficking and protein-protein interactions in live cells
(Massachusetts Institute of Technology, 2008)
Here, we describe our attempts to harness the exquisite specificity of natural protein and RNA enzymes to develop improved methods to study protein localization and protein-protein interactions in live cells. We first ...
Crystallographic studies on enzymatic halogenation of natural products
(Massachusetts Institute of Technology, 2008)
Halogenated natural products are common and serve roles as hormones, pesticides, antibiotics, and anti-tumor agents. The incorporation of a halogen atom into an organic scaffold can tune the molecule's potency and selectivity, ...
Charge transport, configuration interaction and Rydberg states under density functional theory
(Massachusetts Institute of Technology, 2008)
Density functional theory (DFT) is a computationally efficient formalism for studying electronic structure and dynamics. In this work, we develop DFT-based excited-state methods to study electron transport, Rydberg excited ...
Methodology and applications of high resolution solid-state NMR to structure determination of proteins
(Massachusetts Institute of Technology, 2008)
A number of methodological developments and applications of solid-state NMR for assignment and high resolution structure determination of microcrystalline proteins and amyloid fibrils are presented. Magic angle spinning ...
Nickel-catalyzed coupling reactions and synthetic studies toward ent-dioxepandehydrothyrsiferol via an epoxide-opening cascade
(Massachusetts Institute of Technology, 2008)
Nickel-Catalyzed Coupling Reactions. Nickel-catalyzed allene--aldehyde coupling and alkene--aldehyde coupling represent two methods of preparing allylic alcohols. Most asymmetric transition metal-catalyzed methods of ...