Search
Now showing items 11-20 of 226
Dynamic nuclear polarization of amorphous and crystalline small molecules
(Massachusetts Institute of Technology, 2014)
Solid-state NMR has emerged to become an important technique in the studies of pharmaceutical formulations consisting of active pharmaceutical ingredients (API) and excipients. Dynamic nuclear polarization (DNP), which ...
Conformational dynamics control catalysis in disparate systems : structural insights from DNA repair and antibiotic biosynthetic enzymes
(Massachusetts Institute of Technology, 2014)
Chemical reactions allow biological systems to function. The majority of these biochemical reactions occur due to the work of protein catalysts known as enzymes. These biocatalysts are often thought of as pre-formed, static ...
Developments and advances in nonlinear terahertz spectroscopy
(Massachusetts Institute of Technology, 2014)
Nonlinear terahertz (THz) spectroscopy is a rapidly developing field, which is concerned with driving and observing nonlinear material responses in the THz range of the electromagnetic spectrum. In this thesis, I present ...
Structure and function of the Influenza membrane protein M2 by magic angle spinning NMR and dynamic nuclear polarization
(Massachusetts Institute of Technology, 2014)
Determination of the 3D structure of membrane proteins is a frontier that is rapidly being explored due to the importance of membrane proteins in regulating cellular processes and because they are the target of many drugs. ...
High field DNP and cryogenic MAS NMR : novel instrumentation and applications
(Massachusetts Institute of Technology, 2014)
Solid State Nuclear Magnetic Resonance (ssNMR) spectroscopy has blossomed over the last two decades. As ssNMR is progressively applied to more challenging systems, the sensitivity remains one of its major limiting factors. ...
Strategies for combinatorial development of siRNA conjugate delivery systems
(Massachusetts Institute of Technology, 2015)
RNA interference (RNAi), which can reversibly silence the expression of any gene, has vast potential as a therapeutic to treat many diseases. A wide variety of small interfering RNA (siRNA) delivery systems has been studied, ...
Gold-nickel surface alloy chemistry with oxygen and carbon monoxide
(Massachusetts Institute of Technology, 2015)
Key to low temperature carbon monoxide oxidation on gold-nickel random surface alloys is molecularly (rather than atomically) adsorbed oxygen, and weakly bound carbon monoxide. To characterize these adsorbates, saturation ...
An old cofactor in a new light : how nature handles and repurposes adenosylcobalamin
(Massachusetts Institute of Technology, 2015)
Adenosylcobalamin (AdoCbl, coenzyme B 12) is a complex organometallic enzyme cofactor derived from vitamin B 12 that allows for challenging radical-based chemical transformations. Additionally, the biological role of AdoCbl ...
Harnessing inorganic coordination chemistry for novel sensing applications
(Massachusetts Institute of Technology, 2016)
We explore strategies to exploit the rich chemical reactivity available to inorganic coordination complexes in order to realize chemiresistive detectors, electronic device elements that undergo a change in resistance in ...
Real-time observations of materials under dynamic loading conditions at the micron scale
(Massachusetts Institute of Technology, 2016)
New methods are introduced for direct real-time observations of materials under dynamic loading. Traditionally, converging shock waves, which are of great interest for studying fundamental aspects of behavior of materials ...