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Synthetic biology approaches for engineering bacteria as living therapeutics
(Massachusetts Institute of Technology, 2021)
Bacteria and humans have a long-standing symbiotic relationship. As the details of their symbiosis continue to be elucidated, it has become clear that these host-resident bacteria are much more than spectators within the ...
Phosphoproteomics analysis of Alzheimer's disease
(Massachusetts Institute of Technology, 2021)
Alzheimer's disease (AD) is a form of dementia characterized by the appearance of amyloid-[beta] plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Despite numerous clinical trials, a ...
Environmental tuning of the reactivity of molecules confined to polarized interfaces
(Massachusetts Institute of Technology, 2021)
The heterogenization of molecular catalysts to polarized interfaces provides an appealing approach to the design of more efficient and selective electrochemical devices. The well-defined nature of molecular catalysts renders ...
Metrology and mechanics for manufacturing space-based x-ray grating spectrometers
(Massachusetts Institute of Technology, 2021)
Small errors in critical dimensions (CDs) or deformation of optical components can lead to severe performance degradation in high-resolution imaging and spectroscopy tools. Consistent innovations towards more precise optical ...
Computational tools towards automating the scientific method
(Massachusetts Institute of Technology, 2021)
We present a collection of novel computational tools designed to contribute to the goal of large-scale scientific automation. Deep Involutive Neural MCMC and other inference compilation techniques present a promising path ...
Diagnosing the variability in temperature and velocity in the Middle Atlantic Bight
(Massachusetts Institute of Technology, 2021)
Observations of hydrographic and dynamical properties on the Middle Atlantic Bight shelf document strong variability at time scales spanning events that last a few days to century long trends. This thesis studies individual ...
Partial state in dataflow-based materialized views
(Massachusetts Institute of Technology, 2021)
This thesis proposes a practical database system that lowers latency and increases supported load for read-heavy applications by using incrementally-maintained materialized views to cache query results. As opposed to ...
Programmable interfaces for biomedical and neuroscience applications
(Massachusetts Institute of Technology, 2021)
The rapidly changing fields of biomedical sciences and neuroscience increasingly adopt scientific and technological innovations to advance the diagnosis and treatment of disease. With the emergence of miniaturized and ...
Analytics for accelerating biomedical innovation
(Massachusetts Institute of Technology, 2021)
Despite the many breakthroughs in biomedical research and the increasing demand for new drugs to treat unmet medical needs, the productivity of research and development in the pharmaceutical industry has been steadily ...
Development of high-temperature firebrick resistance-heated energy storage (FIRES) using doped ceramic heating system
(Massachusetts Institute of Technology, 2021)
Towards combating climate change, the widespread replacement of fossil fuel energy with zero-carbon energy has two main requirements: (1) the ability to reach very high temperatures using zero-carbon energy to perform a ...