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Transcriptome-wide organization of subcellular microenvironments revealed by ATLAS-Seq
(Massachusetts Institute of Technology, 2020)
Subcellular localization of RNAs is a ubiquitous and evolutionarily conserved process that provides an additional layer of transcriptome organization promoting coordinated control of gene expression in both space and time. ...
A quantitative view of Y-chromosome gene expression across the human body
(Massachusetts Institute of Technology, 2020)
Human Y-chromosome genes have long been known to play pivotal roles in two biological processes--sex determination and spermatogenesis. Recent studies have uncovered evidence that Y-chromosome genes also perform important ...
Characterization of synaptotagmin 7 function in neurotransmission and its subcellular localization at synapses
(Massachusetts Institute of Technology, 2020)
Synaptic vesicle (SV) fusion is dependent on proteins that can sense Ca²⁺ and trigger fusion with the plasma membrane. Neurotransmitter release occurs during a rapid synchronized phase of SV fusion mediated by the Ca²⁺ ...
Engineering probiotic microbes for in vivo applications
(Massachusetts Institute of Technology, 2020)
Our overall goal is to engineer probiotic microbes as localized diagnostic and therapeutic tools for diseases in the gastrointestinal tract, like inflammatory bowel disease. Current treatments often rely on systemic ...
Enhancers and phase separation in the control of gene expression
(Massachusetts Institute of Technology, 2020)
Gene regulation underlies the control of cell identity, development, and disease. Transcription of genes is regulated by DNA elements called enhancers, which are bound by transcription factors and coactivators, leading to ...
Choices in regeneration: position and fate
(Massachusetts Institute of Technology, 2020)
Positional information is required for animal regeneration, yet how it is harbored in adult tissues is poorly understood. In planarians, positional control genes (PCGs) control regeneration outcomes and are regionally ...
The biochemical basis for the cooperative action of microRNAs
(Massachusetts Institute of Technology, 2020)
In metazoans, microRNAs (miRNAs) act to repress mRNAs through a combination of translational repression and target degradation. miRNAs predominantly pair within the 3' untranslated region (3' UTR) of the mRNA. In cells, ...
Molecular, cellular, and circuit analysis of C. elegans spitting behavior
(Massachusetts Institute of Technology, 2020)
To identify the neural and molecular substrates of animal behavior and understand the principles by which they function is a major goal in neurobiology. One simple system for such behavioral studies is the pharynx of the ...
Effects of the mobile genetic element ICEBs1 on bacterial host fitness
(Massachusetts Institute of Technology, 2020)
Mobile genetic elements drive bacterial evolution by mediating horizontal gene transfer and by carrying cargo genes that confer important traits to host cells. Traits provided by mobile genetic elements include antibiotic ...
Functional changes in connectivity induced by differential manipulations of activity in Drosophila tonic versus phasic motoneurons
(Massachusetts Institute of Technology, 2020)
Structural and functional plasticity induced by neuronal competition is a common feature of developing nervous systems. However, the rules governing how postsynaptic cells differentiate between presynaptic inputs are ...