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Structure studies of the human class II major histocompatibility complex protein HLA-DR1
(Massachusetts Institute of Technology, 2004)
Major Histocompatibility Complex (MHC) proteins are heterodimeric membrane glycoproteins that bind antigens in the form of short peptides within the cell and present them to the T cell receptors on the surface T cells. In ...
Copper-catalyzed conjugate reduction
(Massachusetts Institute of Technology, 2004)
Chapter 1. A highly enantioselective catalyst for the asymmetric conjugate reduction of a,- unsaturated cyclic ketones was generated upon combination of catalytic amounts of CuCl, NaOt-Bu, and a chiral bis-phosphine with ...
Slow dynamics in supercooled liquids : matrix formalism, mode coupling and glass transition
(Massachusetts Institute of Technology, 2004)
In this thesis, slow dynamics of supercooled liquids are investigated in the framework of the mode-coupling theory (MCT). Following the real-time generalized Langevin equation in Newtonian liquids, the dynamic Gaussian ...
High-frequency time domain electron paramagnetic resonance : methods and applications
(Massachusetts Institute of Technology, 2004)
There are numerous advantages to high frequency (high field) electron paramagnetic resonance (EPR) spectroscopy. Two of the most important are improved sensitivity and the improved resolution of field dependent interactions. ...
Understanding and engineering the photophysics of single CdSe nanocrystals
(Massachusetts Institute of Technology, 2004)
This thesis focuses on uncovering the photophysics of CdSe semiconductor quantum dots (QDs) at the single QD level, and correlating the phenomenological behavior observed at the single QD level to that observed at the ...
Development and application of transition metal-catalyzed cross-coupling reactions
(Massachusetts Institute of Technology, 2004)
Chapter 1. PALLADIUM-CATALYZED REGIOSELECTIVE HYDRODEBROMINATION OF DIBROMOINDOLES A novel approach to the selective preparation of 4-bromoindoles has been developed via a Pd-catalyzed reaction. A variety of 4,6-dibromoindoles, ...
Mechanistic and synthetic studies of the intramolecular [4+2] cycloaddition of conjugated enynes
(Massachusetts Institute of Technology, 2004)
An examination of the mechanism and scope of the intramolecular [4+2] cycloaddition of conjugated enynes has shown the reaction likely proceeds by a concerted cycloaddition of the enyne to give a highly reactive cyclic ...
Solution-phase and automated solid-phase synthesis of high-mannose oligosaccharides : application to carbohydrate microarrays and biological studies
(Massachusetts Institute of Technology, 2004)
(cont.) 2G12, cyanovirin-N, and a recently identified anti-HIV protein, scytovirin.
Activation of white phosphorus by molybdenum- and uranium tris-amides
(Massachusetts Institute of Technology, 2004)
Molybdaziridine-hydride Mo(H)([eta]²-Me₂C=NAr)(N[i-Pr]Ar)₂ (1, Ar = 3,5-C₆H₃Me₂) acts as a source of its three-coordinate isomer Mo(N[i-Pr]Ar)₃ (2). This relationship has been probed via an investigation of the coordination ...
Asymmetric nickel-catalyzed three-component assembly of allylic amines from alkynes, imines and organoboron reagents
(Massachusetts Institute of Technology, 2004)
[Image] ... Allylic amines are assembled in one step from alkynes, imines, and organoboron reagents (boronic acids or boranes) using a catalyst derived from Ni(cod)2 and (c-CsH9)3P or (o-anisyl)3P. This catalytic, ...