Search
Now showing items 311-318 of 318
Screening, synthesis, and applications of "lipidoids", a novel class of molecules developed for the delivery of RNAi therapeutics
(Massachusetts Institute of Technology, 2008)
RNAi therapeutics represent a fundamentally new way of treating disease, permitting the selective abrogation of protein production at the genetic level. As nucleic acids do not readily enter cells, carriers are utilized ...
Structural investigations of hydroxylase proteins and complexes in bacterial multicomponent monooxygenase systems
(Massachusetts Institute of Technology, 2008)
Bacterial multicomponent monooxgenases (BMMs) such as toluene/o-xylene monooxygenase (ToMO), phenol hydroxylase (PH), and soluble methane monooxygenase (sMMO) catalyze hydrocarbon oxidation reactions at a carboxylatebridged ...
Phonon polariton interaction with patterned materials
(Massachusetts Institute of Technology, 2008)
The generation, propagation and detection of THz phonon polaritons are studied through both femtosecond pump-probe techniques, and Finite Difference Time Domain (FDTD) simulations in this thesis. The theory surrounding the ...
Recent advances in palladium-catalyzed carbon-carbon and carbon-boron bond forming processes
(Massachusetts Institute of Technology, 2008)
Chapter 1. Highly active and efficient catalyst systems derived from palladium precatalysts and monophosphine ligands for the Suzuki-Miyaura cross-coupling reaction of heteroaryl boronic acids and esters has been developed. ...
Progress in transition metal-based enantioselective catalysis
(Massachusetts Institute of Technology, 2008)
In Chapter 1, the first enantioselective cross-coupling reactions of racemic secondary benzylic halides are described (eq 1). This method was applied to the syntheses of intermediates employed by other groups in the ...
Structural studies of amyloid fibrils using solid-state NMR
(Massachusetts Institute of Technology, 2008)
he development of solid-state NMR techniques and application to amyloid fibrils are presented. In addition, a new method of selective inversion based on chemical shift anisotropy is presented. An improved method for highly ...
Investigating asparagine-linked glycosylation substrate : specificity and effects on protein folding
(Massachusetts Institute of Technology, 2009)
N-linked glycosylation is a ubiquitous form of protein modification whereby a preassembled oligosaccharide is covalently attached the asparagine side chain of an acceptor protein. This process involves numerous enzymes, ...
Two versatile cofactors, flavin adenine dinucleotide and non-heme iron, involved in DNA repair and natural product halogenation
(Massachusetts Institute of Technology, 2009)
Cofactors assist enzymes with a variety of complex chemistries. Two versatile cofactors, flavin adenine dinucleotide (FAD) and non-heme iron, together with molecular oxygen as an oxidizing agent, perform a wide array of ...