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The roles of the helicase double-hexamer complex and the ssDNA-binding protein RPA during eukaryotic DNA replication
(Massachusetts Institute of Technology, 2020)
Eukaryotic DNA replication is a complex process that must occur accurately, completely, and only once per cell cycle. To accomplish these goals, the events of DNA replication are tightly coupled to cell-cycle progression. ...
Aneuploidy reveals insights into control of protein complex stoichiometry
(Massachusetts Institute of Technology, 2019)
Aneuploidy, or an incorrect number of chromosomes, is caused by errors in chromosome segregation during cell division. Because genes are expressed in accordance with their copy number, aneuploidy simultaneously alters the ...
Endoribonuclease toxin-antitoxin systems in bacteria : targets and growth inhibition
(Massachusetts Institute of Technology, 2019)
Toxin-antitoxin (TA) systems are widely-distributed genetic modules that can reversibly inhibit the host bacteria's growth. Both toxin and antitoxin are encoded together on an operon and the antitoxin directly binds the ...
Physiological and behavioral responses, and their variability, in squid, Doryteuthis pealeii, embryos and paralarvae reared under chronic ocean acidification
(Massachusetts Institute of Technology, 2019)
Ocean acidification (OA) and related stressors, like warming, are occurring rapidly in coastal systems. There is concern about the impacts these stressors may have on the early development of species that use the nearshore ...
Combinatorial gene regulation by transcription factors
(Massachusetts Institute of Technology, 2019)
Combinatorial gene regulation is encoded in enhancers and promoters in the form of binding sites for transcription factors (TFs), which collaboratively recruit the transcriptional machinery and drive gene expression. Using ...
Comprehensive single-cell transcriptional profiling of the regenerative planarian Schmidtea mediterranea
(Massachusetts Institute of Technology, 2020)
Animals can contain hundreds of cell types, each of which has a distinct morphology and function. The transcriptome of a cell dictates this unique cell biology. Recent approaches for high throughput single-cell RNA sequencing ...
Tool development for the rapid identification of microbiome manipulating agents
(Massachusetts Institute of Technology, 2020)
Manipulation of complex microbial communities, such as human microbiomes, plays a critical role in the study and treatment of microbiome associated diseases. However, the tools available to perform microbiome manipulations ...
Genetic regulation of cell extrusion in caenorhabditis elegans
(Massachusetts Institute of Technology, 2019)
Programmed elimination of cells occurs during animal development and homeostasis to maintain appropriate cell numbers. One evolutionarily conserved method by which organisms eliminate cells in a programmed manner is by ...
Impacts of developmental exposures to the harmful algal bloom toxin domoic acid on neural development and behavior
(Massachusetts Institute of Technology, 2019)
Harmful algal blooms (HABs) can produce potent neurotoxins that accumulate in seafood and affect human health. One HAB toxin of concern is domoic acid (DomA), a glutamate analog produced by the marine diatom Pseudo-nitzschia ...
Characterizing the ecology of coral reef microorganisms across different scales within the Caribbean
(Massachusetts Institute of Technology, 2020)
Microorganisms sustain the high productivity of coral reefs and support one of the most diverse, valuable, and threatened ecosystems on Earth. Despite the importance of reef microorganisms, there is a lack of understanding ...