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Robust genome editing with broad-targeting CRISPR enzymes
(Massachusetts Institute of Technology, 2020)
Programmable CRISPR enzymes are powerful and versatile tools for genome editing. They, however, require a specific protospacer adjacent motif (PAM) flanking the target site, which constrains the accessible sequence space ...
Polarization and toxicity in political discourse online
(Massachusetts Institute of Technology, 2020)
The web and social media promised to fundamentally change the public sphere by democratizing access to information and lowering barriers for participation in public discourse. While some of these expectations have been ...
Digital expressive media for supporting early literacy through child-driven, scaffolded play
(Massachusetts Institute of Technology, 2020)
Digital technology holds many promises for supporting early literacy development. To stimulate both l earning achievement and children's interest in literacy, i t i s beneficial f or a l earning activity to be playful, ...
Resynthesizing volumetric soundscapes : low-rank subspace methods for soundfield estimation and reconstruction
(Massachusetts Institute of Technology, 2020)
Sound and space are fundamentally intertwined, at both a physical and perceptual level. Sound radiates from vibrating materials, filling space and creating a continuous field through which a listener moves. Despite a long ...
Discrete mechanical metamaterials
(Massachusetts Institute of Technology, 2020)
Digital fabrication enables complex designs to be realized with improved speed, precision, and cost compared to manual techniques. Additive manufacturing, for example, is one of the leading methods for rapid prototyping ...
From data physicalization to data experiences : combining art, science, technology, and community to move towards collective action on environmental challenges
(Massachusetts Institute of Technology, 2020)
The environmental risks our society faces are becoming increasingly urgent and may have devastating implications both locally and globally. Over the past 40 years, environmental efforts have built understanding and have ...
Autonomic activity from human videos
(Massachusetts Institute of Technology, 2020)
The autonomic nervous system (ANS) is a part of the nervous system that is responsible for regulation and integration of internal organs' functioning. Traditionally, for the assessment of the ANS function, autonomic activity ...
Self-aware self-assembly for space architecture : growth paradigms for in-space manufacturing
(Massachusetts Institute of Technology, 2020)
Humanity stands on the cusp of interplanetary civilization. As we prepare to venture into deep space, we face what appears to be an irreconcilable conundrum: at once a majestic domain for human exploration, while also a ...
Translational design computation
(Massachusetts Institute of Technology, 2021)
Synergetic tensions have evolved the dichotomy between the physical and digital design domains into a symbiotic unity. New capabilities in digital fabrication give rise to sophisticated tools of computational design, while ...
Technology-assisted coaching : a system for Children's literacy learning
(Massachusetts Institute of Technology, 2021)
Children learn best when knowledgeable adults support their learning process. Yet many learning technologies have not yet incorporated this vital social dimension. In response, we develop a technology-assisted coaching ...