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Molecular and polymeric films formed on silicon by solution-phase reactions
(Massachusetts Institute of Technology, 2000)
This thesis details studies of the chemical reactivity of silicon surfaces and the development of new reactions for manipulating its surface properties by the formation of covalently attached molecular and polymeric films. ...
Fluorescence fluctuation spectroscopy and microscopy : application to cellular molecular dynamics and organization
(Massachusetts Institute of Technology, 2016)
Fluorescence fluctuation spectroscopy and microscopy have been powerful tools for studying molecular organization and dynamics in cells. Fluorescence Correlation Spectroscopy (FCS) has been widely applied to probing molecular ...
Nanomechanical systems with small dissipation
(Massachusetts Institute of Technology, 2015)
This thesis is devoted to a systematic development of methods for controlling energy dissipation in small mechanical systems, specifically nanomechanical resonators with at least one dimension in the deep nanometer range ...
Enantioselective total syntheses of acylfulvene, irofulven, and the agelastatins
(Massachusetts Institute of Technology, 2010)
I. Enantioselective Total Synthesis of (-)-Acylfulvene, and (-)-Irofulven We report the enantioselective total synthesis of (-)-acylfulvene and (-)-irofulven, which features metathesis reactions for the rapid assembly of ...
Spatially restricted proteomic mapping of excitatory and inhibitory post-synaptic termini through enzymatic labeling
(Massachusetts Institute of Technology, 2016)
The neuronal synapse is the seat of cognitive computation in the brain, where the minor adjustments in electrical activity between various neuronal circuits results from the sophisticated orchestration of molecules at the ...
Progress towards the total synthesis of chlorothricolide
(Massachusetts Institute of Technology, 1982)
Stereochemical aspects of the intramolecular Diels-Alder reaction
(Massachusetts Institute of Technology, 1982)
Structure studies of the human class II major histocompatibility complex protein HLA-DR1
(Massachusetts Institute of Technology, 2004)
Major Histocompatibility Complex (MHC) proteins are heterodimeric membrane glycoproteins that bind antigens in the form of short peptides within the cell and present them to the T cell receptors on the surface T cells. In ...
Copper-catalyzed conjugate reduction
(Massachusetts Institute of Technology, 2004)
Chapter 1. A highly enantioselective catalyst for the asymmetric conjugate reduction of a,- unsaturated cyclic ketones was generated upon combination of catalytic amounts of CuCl, NaOt-Bu, and a chiral bis-phosphine with ...
Functionalization and fabrication of single-walled carbon nanotube-based chemiresistors for sensory applications
(Massachusetts Institute of Technology, 2015)
Chemical sensors that identify and monitor volatile organic compounds (VOCs) have an important role in assessing public security, food and water quality, industrial environment, and health. The fabrication of carbon-based ...