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Now showing items 971-980 of 1071
Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma
(Massachusetts Institute of Technology, 2023-06)
Apicomplexan parasites use Ca²⁺-regulated exocytosis to secrete essential virulence factors from specialized organelles called micronemes. Ca²⁺-dependent protein kinases (CDPKs) are required for microneme exocytosis; ...
Comparison of wild-type and hotspot mutant p53 interactomes: The hunt for mutant-specific binding partners & Investigation and characterization of natural killer cell responses in genetically-engineered mouse models of non-small cell lung cancer
(Massachusetts Institute of Technology, 2022-02)
Part 1: The most frequently mutated gene in human cancer is the tumor suppressor gene p53, which is routinely found to have missense mutations at recurrent hotspot residues. Investigations of mutant p53 hotspot variants ...
Structure and function of a class A macrophage scavenger receptors
(Massachusetts Institute of Technology, 1996)
Positional cloning of nude, a fork head transcription factor : genetic, physical and transcriptional maps of the region and mutations in the mouse and rat
(Massachusetts Institute of Technology, 1996)
DegP related proteases in Escherichia coli and carboxyl-terminal tagging of proteins for degradation
(Massachusetts Institute of Technology, 1996)
Modeling hematologic malignancies and their treatment in humanized mice
(Massachusetts Institute of Technology, 2010)
Approximately 10% of all cancer deaths in the United States are due to neoplasms of the hematopoietic system, such as leukemias and lymphomas. Genetically engineered mouse models of these diseases have yielded invaluable ...
Functional characterization and expression of molluscan detoxification enzymes and transporters involved in dietary allelochemical resistance
(Massachusetts Institute of Technology, 2008)
Understanding how organisms deal with potentially toxic or fitness-reducing allelochemicals is important for understanding patterns of predation and herbivory in the marine environment. The ability of marine consumers to ...
Identification of novel genes regulated by innervation and characterization of subsynaptic proteins in skeletal muscle
(Massachusetts Institute of Technology, 1997)
Cell-cell signaling and the regulation of development in Bacillus subtilis
(Massachusetts Institute of Technology, 1997)
Selective delivery of membrane proteins to the cell surface in Saccharomyces cerevisiae
(Massachusetts Institute of Technology, 1997)