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Multi-mode two-dimensional infrared spectroscopy of peptides and proteins
(Massachusetts Institute of Technology, 2008)
In this thesis, a methodology for understanding structural stability of proteins through multi-mode two-dimensional infrared (2D IR) spectroscopy is developed. The experimental framework for generation of broadband infrared ...
Mechanistic investigation of coordinated conformational changes in multisubunit ion channels and enzymes
(Massachusetts Institute of Technology, 2008)
Many enzymes and ion channels consist of multiple subunits and/or multiple distinct functional components. Coordinated conformational changes through allosteric interactions between subunits and/or between functional units ...
Studies directed towards the total synthesis of (+)-sieboldine A
(Massachusetts Institute of Technology, 2008)
Progress towards the total synthesis of sieboldine A is described. This synthetic approach uses a nickel-catalyzed alkyne-ketone reductive cyclization to form the hydrindane core of the natural product in good yield and ...
The detection of nitric oxide and its reactivity with transition metal thiolate complexes
(Massachusetts Institute of Technology, 2008)
Nitric oxide (NO) is a molecule that is essential for life and regulates both beneficial and harmful processes. Because this gaseous radical influences many aspects of health and disease, we wish to explore the relationship ...
Polymers containing calix[4]arenes and triptycenes : new syntheses, properties and applications
(Massachusetts Institute of Technology, 2008)
This thesis details the development of new synthetic methods for making polymers with complex molecular structures. Calix[4]arenes and triptycenes are the two major molecular building blocks for constructing the functional ...
Observing the unfolding transition of [beta]-hairpin peptides with nonlinear infrared spectroscopy
(Massachusetts Institute of Technology, 2008)
The biological function of a protein is in large measure determined by its three-dimensional structure. To date, however, the transition of the protein between the native and non-native conformations is not well-understood. ...
Colloidal semiconductor nanocrystals as nanoscale emissive probes in light emitting diodes and cell biology
(Massachusetts Institute of Technology, 2008)
This thesis employs colloidal semiconductor nanocrystals (NCs) as nanoscale emissive probes to investigate the physics of light emitting diodes (LEDs), as well as to unveil properties of cells that conventional imaging ...
Ultrafast dynamic ellipsometry of laser driven shock waves
(Massachusetts Institute of Technology, 2008)
The experimental measurement technique of ultrafast dynamic ellipsometry (UDE) was developed for measuring material motion and changes in optical properties of samples under laser driven shock loading. Ultrafast dynamic ...
Mechanism of the efficient quenching of tryptophan fluorescence in human gamma crystallin
(Massachusetts Institute of Technology, 2008)
Quenching of the fluorescence of buried tryptophans (Trps) is an important reporter of protein conformation. Human [gamma]D-crystallin (H[gamma]D-Crys) and human [gamma]S-crystallin (H[gamma]S-Crys) are both very stable ...
Synthesis, structure, and magnetic properties of spin-1/2 kagomé antiferromagnets
(Massachusetts Institute of Technology, 2008)
Stoichiometrically pure S = 1/2 Cu2+ kagomé materials have been synthesized. Such materials provide an ideal venue for exploration of quantum states on a kagomé because they exhibit strong geometric spin frustration and ...