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Thermodynamic and transport property modeling in super critical water
(Massachusetts Institute of Technology, 2005)
Supercritical water oxidation (SCWO) is a thermally-based, remediation and waste-treatment process that relies on unique property changes of water when water is heated and pressurized above its critical point. Above its ...
A statistical framework for extraction of structured knowledge from biological/biotechnological systems
(Massachusetts Institute of Technology, 2003)
Despite enormous efforts to understand complex biological/biotechnological systems, a significant amount of knowledge has still remained unraveled. However, recent advances in high throughput technologies have offered new ...
Cardiac tissue engineering : bioreactor cultivation parameters
(Massachusetts Institute of Technology, 2000)
Tissue engineering may be useful in fighting heart disease since it offers the possibility of creating functional tissue equivalents for scientific studies and tissue repair. In the present work, we examined how variations ...
Thermodynamics and kinetics of antisense oligonucleotide hybridization to a structured mRNA target
(Massachusetts Institute of Technology, 2002)
Antisense oligonucleotides have the potential to selectively inhibit the expression of any gene with a known sequence. Antisense-based therapies are under development for the treatment of infectious diseases as well as ...
Temporal evolution of intracellular signaling and gene expression following patterns of membrane depolarization in the pheochromocytoma cell line, PC 12
(Massachusetts Institute of Technology, 2003)
An experimental study was performed to characterize the effects of different patterns of membrane depolarization on undifferentiated pheochromocytoma (PC 12) cells. In response to chronic depolarization, cytoplasmic free ...
Elucidation of chemically-induced transdermal transport processes
(Massachusetts Institute of Technology, 2002)
In this thesis, chemically-induced transdermal transport enhancement has been examined as one of the many techniques currently used to increase the skin permeability to a broader range of pharmaceutically relevant drugs. ...