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Tissue specific regulation of the high density lipoprotein (HDL) receptor, scavenger receptor Class B, Type I (SR-BI) by the scaffold protein PDZK1
(Massachusetts Institute of Technology, 2008)
PDZK1 is a four PDZ-domain containing cytoplasmic adaptor protein that binds the Cterminus of the high-density lipoprotein (HDL) receptor SR-BI. Abolishing PDZK1 expression in PDZK1 knockout (KO) mice leads to a ...
Identification of new functions for BRCT domains
(Massachusetts Institute of Technology, 2008)
Our lab identified the tandem BRCT domains of PTIP function as a DNA damage responsive phospho binding domain that recognizes proteins phosphorylated by ATM and ATR after DNA damage. The PTIP tandem BRCT domains are ...
Sequence of the mouse Y chromosome
(Massachusetts Institute of Technology, 2008)
The mouse Y chromosome has been studied for over 50 years, from the early sex determination and immunological phenotypes attributed to it in the 1950s, to the several mouse Y permatogenic phenotypes and the sex ratio ...
An evolutionary perspective on the sequence, mechanism, and regulatory function of animal microRNAs
(Massachusetts Institute of Technology, 2008)
(cont.) The vertebrate-specific miR-196 family is encoded at three paralogous loci in the mammalian Hox clusters, and has complementarity to messages of several Hox genes, including Hox8 paralogues. RNA fragments diagnostic ...
Control of HslUV protease function by nucleotide binding and hydrolysis
(Massachusetts Institute of Technology, 2008)
Many proteins act as molecular machines, using the power of nucleotide binding and hydrolysis to drive conformational changes in themselves and their target substrates. Like other AAA+ proteases, HslUV recognizes, unfolds, ...
Functional analysis of the microRNA genes of C. elegans
(Massachusetts Institute of Technology, 2008)
MicroRNAs (miRNAs) were discovered in C. elegans during studies of the control of developmental timing. MicroRNAs are a large class of short non-coding RNAs found in many viruses, plants and animals that regulate gene ...
C. elegans integrates food, stress, and hunger signals to coordinate motor activity
(Massachusetts Institute of Technology, 2008)
In the presence of a bacterial food source, the small nematode C. elegans greatly reduces its rate of locomotion. While mechanical agitation greatly stimulates the locomotion of well-fed animals on bacteria, it does not ...
Roles for motifs of cell cycle regulating kinases beyond substrate selection of individual kinases
(Massachusetts Institute of Technology, 2008)
Errors in the cell cycle, particularly during mitosis, have recently been implicated in tumorigenesis and cancer formation. Several protein kinases, including the major mitotic kinases Cdkl, Aurora A, Aurora B, Nek2, and ...
Insights into the regulation of mTOR signaling and the consequences of pharmacological inhibition
(Massachusetts Institute of Technology, 2008)
Cells have evolved a highly tuned system for driving growth in response to the right cues. Permissive signals initiate a cascade of events that send nutrient transporters to the membrane, suppress apoptosis, boost protein ...
Mammalian gene regulation through the 3' UTR
(Massachusetts Institute of Technology, 2008)
The untranslated region (UTR) at the 30 end of a mammalian mRNA is typically rich with regulatory motifs that influence the stability, localization, translation and other properties of the message. We explored two classes ...