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Understanding and improving the anticancer activity of cisplatin
(Massachusetts Institute of Technology, 2001)
The purpose of this thesis is to further our understanding of the mechanism of action of cis-diamminedichloroplatinum(II) (cisplatin), one of the most effective anticancer drugs. Since its serendipitous discovery in 1970, ...
Sensitivity-enhanced nuclear magnetic resonance of biological solids
(Massachusetts Institute of Technology, 2001)
Dynamic Nuclear Polarization (DNP) enhances the sensitivity of solid-state Nuclear Magnetic Resonance experiments via transfer of polarization from electrons to nuclei. The polarization transfer is driven by microwave ...
Transition-metal catalysis of cyclocarbonylation and cycloisomerization reactions
(Massachusetts Institute of Technology, 2001)
Chapter 1. The asymmetric Pauson-Khand cyclization of nitrogen-containing enynes using carbon monoxide and a catalytic amount of (EBTHI)TiMe2 was examined. The influence of the nitrogen substituent and the concentration ...
Synthesis, characterization, and reactivity of low valent technetium phosphine complexes
(Massachusetts Institute of Technology, 2001)
Chapter 1. The chemistry of the metal-metal multiply bonded Tc2(II,II) core has been investigated with bis(diphenylphosphino)methane (dppm). The parent complex, Tc2Cl4(dppm)2, has been prepared from the reaction of ...
Synthesis and characterization of cobalt nanocrystals
(Massachusetts Institute of Technology, 2001)
Although several theoretical models for the behavior of magnetic crystals smaller than a single domain size were developed in the 1950's and 60's, they have hardly been verified experimentally because of the lack of ...
Synthetic approaches to new three coordinate Group 6 compounds : chromium alkenyls, molybdenum thiolates and tungsten amides
(Massachusetts Institute of Technology, 2001)
A series of alkenyl (-C[Ad]Ar) and thioalkenyl (-SC[Ad]Ar, Ad=2-adamantylidene, Ar=3,5-Me2C6H3, 4-tBuC6H4, 3,5-(C6H5)2C6H3, 3,5-(4-tBu-C6H4)2 C6H3) ligands have been prepared. The alkenyl ligands are synthesized by bromination ...
Two-electron mixed-valence complexes small molecule activation and photocatalytic hydrogen production
(Massachusetts Institute of Technology, 2001)
Two-electron mixed-valence complexes of rhodium may be supported by diphosphazane ligands (RN(PY2)2). Whereas diphosphazane ligands with strongly [pi]-acidic phosphine groups (Y = F, OCH2CF3) react with RhI starting materials ...
Intersystem crossing in acetylene : a mechanistic study
(Massachusetts Institute of Technology, 2001)
The triplet electronic states of acetylene and the intersystem crossing process that populates these states were studied using a second-generation, supersonic jet molecular beam machine with a multispectral capability. ...
Towards incorporation of catalytic function into small folded peptide scaffolds
(Massachusetts Institute of Technology, 2001)
This thesis describes the development of iterative and combinatorial methods for identifying small peptide scaffolds able to support catalytic function. The incorporation of thiamine coenzyme functionality into small peptide ...