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Modeling the active sites of non-heme diiron metalloproteins with sterically hindered carboxylates and syn N-Donor ligands
(Massachusetts Institute of Technology, 2009)
Chapter 1. Different Synthetic Approaches to Modeling the Active Sites of Carboxylate-Bridged Non-Heme Diiron Enzymes Carboxylate-bridged non-heme diiron enzymes activate dioxygen to perform a variety of biological functions. ...
Modeling and analysis of single-molecule experiments
(Massachusetts Institute of Technology, 2005)
Single molecule experiments offer a unique window into the molecular world. This window allows us to distinguish the behaviors of individual molecules from the behavior of bulk by observing rare events and heterogeneity ...
Optical studies of DNA-wrapped carbon nanotubes
(Massachusetts Institute of Technology, 2006)
This thesis presents a series of detailed optical studies of phonon-assisted relaxation processes in DNA-wrapped single walled carbon nanotubes. Using resonance Raman spectroscopy (RRS) and photoluminescence spectroscopy ...
Synthetic and mechanistic study of catalytic dintrogen reduction
(Massachusetts Institute of Technology, 2006)
The dinitrogen reduction capability of a series of new triamidoamine based molybdenum compounds has been studied. The synthesis of a number of different triamidoamine ligands, and their resulting molybdenum compounds, is ...
Metal-based turn-on fluorescent probes for nitric oxide sensing
(Massachusetts Institute of Technology, 2006)
Chapter 1. Metal-Based Turn-On Fluorescent Probes for Sensing Nitric Oxide. Nitric oxide, a reactive free radical, regulates a variety of biological processes. The absence of tools to detect NO directly, rapidly, specifically ...
Two-dimensional polymer synthesis : towards a two-dimensional replicating system for nanostructures
(Massachusetts Institute of Technology, 2005)
The general concept of a replicating monolayer system is introduced as a new method of nanostructure synthesis. One possible implementation of a 2-D replicating system is pursued which uses a diacetylene moiety for ...
Study of poly(phenylene ethynylene)s, dendritic quenchers, and molecular beacons towards the application of a poly(phenylene ethynylene)-based biosensor
(Massachusetts Institute of Technology, 2007)
Poly(para-phenylene ethynylene)s (PPE)s are highly emissive conjugated polymers that are easily quenched by target analytes. As a result, they have been increasingly incorporated into sensing platforms, both as chemosensors ...
Early transitional metal alkyl, alkylidene, and alkylidyne chemistry
(Massachusetts Institute of Technology, 2007)
CHAPTER 1. Zirconium and hafnium complexes of several new unsymmetric diamide ligands have been prepared and their proficiency in olefin polymerization reactions evaluated. The first set of supporting ligands examined are ...
Proton-coupled electron transfer : from basic principles to small molecule activation
(Massachusetts Institute of Technology, 2007)
Proton-coupled electron transfer (PCET) is the basic mechanism for bioenergetic conversion. Hallmark examples of such reactivities include water oxidation which is coupled to photosynthesis and oxygen reduction which is ...
Non-traditional platinum compounds for improved cellular accumulation and tumor targeting
(Massachusetts Institute of Technology, 2009)
Chapter 1. Introduction to Non-Traditional Platinum Compounds for Improved Uptake, Oral Bioavailability, and Tumor Targeting The path to more potent platinum anticancer drugs with fewer side effects lies in the exploration ...