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Transcription and mismatch repair in the mechanism of action of the anticancer drug cisplatin
(Massachusetts Institute of Technology, 1997)
cis-Diamminedichloroplatinum(II) (cis-DDP or cisplatin) is a powerful cytotoxin and anticancer therapeutic, used most effectively in the treatment of testicular and ovarian cancers. By contrast, the geometric isomer of ...
Application of organosilanes in [3 + 2] annulation approaches to carbocyclic compounds
(Massachusetts Institute of Technology, 1999)
The interactions of molecular fluorine and xenon difluoride with silicon
(Massachusetts Institute of Technology, 1999)
Hydrogen bonding in aqueous solution and peptide helicity studied using model systems
(Massachusetts Institute of Technology, 1999)
Development of asymmetric catalysts based on planar-chiral [pi]-complxes of nigrogen heterocycles with iron
(Massachusetts Institute of Technology, 1999)
A new approach to introducing asymmetry into nucleophilic catalysts while minimizing steric bulk in the vicinity of the nucleophilic atom was explored. Because many of the most effective nucleophilic catalysts have planar ...
Influence of DNA sequence context on O⁶-methylguanine mutagenicity in Escherichia coli
(Massachusetts Institute of Technology, 1999)
Synthesis, characterization and reactivity of organometallic Zr(IV) carboxylate and titanium aminotroponiminate complexes
(Massachusetts Institute of Technology, 1999)
The synthesis and structure of several Zr(IV) carboxylate complexes are described in which the bridging carboxylate is the dianion of 111-xylylenediamine bis(Kemp's triacid imide) (H2XDK) or the more soluble propyl derivative ...
Development and application of palladium-catalyzed carbon-nitrogen bond forming reactions
(Massachusetts Institute of Technology, 1999)
Chapter 1. Pd-Catalyzed Cross-Coupling of a-Substituted Optically Active Amines with Aryl Bromides. The palladium-catalyzed coupling reaction of enantiomerically enriched a-substituted amines with aryl bromides is described. ...
Development and applications of enantioselective organometallic catalysts : I. Organotin catalysts; and, II. Planar-chiral nitrogen heterocyclic catalysts
(Massachusetts Institute of Technology, 1999)
Catalytic osmylation of dienes : mechanistic studies and applications to the stereoselective synthesis of polyols
(Massachusetts Institute of Technology, 1991)