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MicroRNAs (miRNAs) play roles in diverse developmental processes and cellular differentiation. Distinct miRNAs have hundreds to thousands of conserved binding sites in mRNAs, but typically exert only modest repression on ...

One of the major public health concerns of the modern day is the emergence and spread of extensively antibiotic-resistant pathogens. We have already seen the arrival of infections caused by bacteria resistant to all available ...

To identify the neural and molecular substrates of animal behavior and understand the principles by which they function is a major goal in neurobiology. One simple system for such behavioral studies is the pharynx of the ...

Mobile genetic elements drive bacterial evolution by mediating horizontal gene transfer and by carrying cargo genes that confer important traits to host cells. Traits provided by mobile genetic elements include antibiotic ...

Gains or losses of entire chromosomes lead to aneuploidy, a condition tolerated poorly in all eukaryotes analyzed to date. How aneuploidy affects organismal and cellular physiology is only beginning to be understood. ...

The clinical success of immune checkpoint blockade in the treatment of various cancers provides proof-of-concept that disrupting tumor immune tolerance is an effective therapeutic strategy. Nevertheless, only a subset of ...

The Drosophila follicle cell amplicons are a well-established model system of origin firing, and have been extensively used to investigate the cis and trans-acting elements that govern origin regulation in metazoan ...

Proteins that modify chromatin architecture are important drivers of leukemia. Many genetic lesions in hematopoietic malignancies lead to altered function of one or more chromatin-modifying proteins, often resulting in ...

Programmed cell death is an evolutionarily conserved process that plays critical roles in normal animal development and has been extensively studied in C. elegans. During programmed cell death, caspases are activated in ...

Mitochondria are essential organelles that carry out a multitude of important metabolic processes in mammalian organisms. These processes include ATP generation by the respiratory chain, aspartate synthesis by matrix ...