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Vanadium and chromium complexes supported by sterically demanding ligands : studies relevant to the reduction of dinitrogen to ammonia
(Massachusetts Institute of Technology, 2006)
Chapter 1. Using the [HIPTN3N]3- ligand ([HIPTN3N]3- = [(HIPTNCH2CH2)3N]3-; HIPT = 3,5-(2,4,6-i-Pr3C6H2)2C6H3 = HexaIsoPropylTerphenyl), green paramagnetic [HIPTN3N]V(THF) (1) can be prepared from VCl3(THF)3. Reduction of ...
Quantum dot-based nanomaterials for biological imaging
(Massachusetts Institute of Technology, 2006)
Quantum dot-based fluorescent probes were synthesized and applied to biological imaging in two distinct size regimes: (1) 100-1000 nm and (2) < 10 nm in diameter. The larger diameter range was accessed by doping CdSe/ZnS ...
Nitrene transfer reactions by late transition metal complexes
(Massachusetts Institute of Technology, 2007)
This thesis presents nitrene transfer reactions that are catalyzed or mediated by late transition metal complexes. Sterically large, fluorinated supporting ligands are used to minimize potential side reactions. A new ...
Caged phosphopeptides and phosphoproteins : probes to dissect the role of phosphorylation in complex signaling pathways
(Massachusetts Institute of Technology, 2007)
Protein phosphorylation is a central regulatory mechanism in signal transduction pathways and cellular migration. Current genetic strategies for the study of phosphorylation, including gene knockout and point mutation, are ...
Synthesis and solution state self-assembly of linear-dendritic block copolymers
(Massachusetts Institute of Technology, 2007)
Linear-dendritic block copolymers consisting of a poly(styrene) linear block and poly(amidoamine) dendrimer block were synthesized and examined for their ability to self-assemble in both aqueous environments and organic/aqueous ...
Quantum chemistry for spectroscopy : a tale of three spins (S = 0, 1/2, and 1)
(Massachusetts Institute of Technology, 2007)
Three special topics in the field of molecular spectroscopy are investigated using a variety of computational techniques. First, large-amplitude vibrational motions on ground-state singlet (S0) potential energy surfaces ...
Multi-mode two-dimensional infrared spectroscopy of peptides and proteins
(Massachusetts Institute of Technology, 2008)
In this thesis, a methodology for understanding structural stability of proteins through multi-mode two-dimensional infrared (2D IR) spectroscopy is developed. The experimental framework for generation of broadband infrared ...
[4+2] cycloadditions of iminoacetonitriles : a general strategy for the synthesis of quinolizidines, indolizidines, and piperidines
(Massachusetts Institute of Technology, 2007)
Iminoacetonitriles participate as reactive dienophiles in intermolecular and intramolecular Diels-Alder cycloadditions leading to quinolizidines, indolizidines, and piperidines. The resultant a-amino nitrile cycloadducts ...
Understanding and improving the anticancer activity of cisplatin
(Massachusetts Institute of Technology, 2001)
The purpose of this thesis is to further our understanding of the mechanism of action of cis-diamminedichloroplatinum(II) (cisplatin), one of the most effective anticancer drugs. Since its serendipitous discovery in 1970, ...
Novel function and regulation of mutagenic DNA polymerases in Escherichia coli
(Massachusetts Institute of Technology, 2007)
The observation that mutations in the Escherichia coli genes umuC+ and umuD+ abolish mutagenesis induced by UV-light strongly supported the counterintuitive notion that such mutagenesis is an active rather than passive ...