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The role of the phasin PhaP in promoting polyhydroxybutyrate (PHB) granule formation in Caulobacter crescentus
(Massachusetts Institute of Technology, 2013)
Polyhydroxybutyrate (PHB) is a biodegradable polymer produced by many microorganisms when they find themselves limited in an essential nutrient such as nitrogen or phosphorus but in the presence of an abundant carbon source. ...
Antiviral polymeric drugs and surface coatings
(Massachusetts Institute of Technology, 2013)
Viruses are a major cause of human morbidity and mortality in the world. New effective approaches to stop their spread are paramount. Herein, two approaches toward this goal are explored: (i) developing multivalent ...
Enhancing pharmaceutical formulations to improve efficacy and delivery of drug molecules
(Massachusetts Institute of Technology, 2013)
Major impediments to the full utility of current and potential drugs include issues of resistance and delivery. To address these challenges, in this thesis two directions of research were pursued: (1) the use of multivalent ...
Structural studies of allosteric regulation in the class Ia Ribonucleotide reductase from Escherichia coli
(Massachusetts Institute of Technology, 2013)
Ribonucleotide reductase (RNR) converts ribonucleotides to deoxyribonucleotides, the building blocks for DNA replication and repair. The E. coli class Ia enzyme requires two subunits to catalyze the radical-based reduction ...