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Characterization of the cost of forecast error in a complex supply chain
(Massachusetts Institute of Technology, 1998)
The importance of forecast accuracy is increasing in the semiconductor industry due to two compounding factors. The complexity of the manufacturing process is increasing which causes manufacturing cycle times to increase ...
Antibody drug discovery: From Idea to Biotherapeutic Molecule
(Massachusetts Institute of Technology, 2016)
Graybel (a fictitious name used for privacy reasons) is a large developer of pharmaceuticals. Graybel's Antibody Protein Engineering Group (APEG) is responsible for early stage drug development of biotherapeutic molecules. ...
Implementation of automated visual inspection machines in biopharmaceutical industry
(Massachusetts Institute of Technology, 2019)
Currently, manual visual inspection is the gold standard for the required visual inspection of particulate matter in parenteral medicines. Automated visual inspection machines offer an opportunity for Amgen to improve ...
Investigating the feasibility and impact of integrating wire-arc additive manufacturing in aerospace tooling applications
(Massachusetts Institute of Technology, 2020)
The use of wire-arc additive manufacturing (WAAM) as fabrication method for Iron-Nickel 36 (Invar36) alloy aerospace tooling is a growing area of interest for many tooling companies and composite aircraft manufacturers. ...
Applications of risk pooling for the optimization of spare parts with stochastic demand within large scale networks
(Massachusetts Institute of Technology, 2020)
Amazon is able to deliver millions of packages to customers every day through its Fulfillment Center (FC) network that is powered by miles of material handling equipment (MHE) such as conveyor belts. Unfortunately, this ...
Benchmarking environmental efficiency of garment factories to understand the value of real-time environmental data
(Massachusetts Institute of Technology, 2020)
Li & Fung works with over 10,000 factories distributed across 50 countries to design, produce, and deliver hard- and soft- goods to over 2,000 apparel and consumer goods customers. An increasingly prevalent focus of the ...
Cost of complexity : mitigating transition complexity in mixed-model assembly lines
(Massachusetts Institute of Technology, 2020)
The Nissan Smyrna automotive assembly plant is a mixed-model production facility which currently produces six different vehicle models. This mixed-model assembly strategy enables the production level adjustment of different ...
Floor entry task prioritization for highly automated fulfillment centers
(Massachusetts Institute of Technology, 2020)
As automation continues to gain prevalence within the retail industry, informed decision-making by users of robotic systems is critical for management of throughput and operating expenditures. On robotic fulfillment floors, ...
Connected factory: real time data analysis for manufacturing efficiency
(Massachusetts Institute of Technology, 2020)
Pratt and Whitney is expecting an increase in demand for new engines and for parts supportive of aftermarket service, maintenance, and repair. To avoid expensive capital investments in additional production capacity, Pratt ...
Stepping toward a smarter factory at Canam
(Massachusetts Institute of Technology, 2020)
Canam Group ("Canam") is a manufacturer of steel components and building products used in the construction industry. The company uses a distributed network of manufacturing centers throughout North America to build and ...