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Cell fate reprogramming using transcription factor feedback overexpression
(Massachusetts Institute of Technology, 2018)
Recent advances in stem cell research has demonstrated that the fate of a terminally differentiated cell can be reverted back to pluripotency. The ability to reprogram a differentiated cell back to its undifferentiated, ...
Loading as a design parameter for genetic circuits
(Massachusetts Institute of Technology, 2016)
Since the 2000s, there have been several forms of synthetic genetic circuits that have been modeled and experimentally validated. Examples include the toggle switch, repressilator, various configurations of oscillators, ...