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Browsing Synthetic Biology by Title

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  • DARPA BioComp Plasmid Distribution 1.00 of Standard Biobrick Components 
    Knight, Thomas (MIT Artificial Intelligence Laboratory, 2002-05-22)
    This distribution consists of 300 ng aliquots of plasmid DNA for each of twelve components and compound constructs utilizing our idempotent assembly strategy. The dried DNA should be stable at room temperature for many ...
  • Definitions and Measures of Performance for Standard Biological Parts 
    Conboy, Caitlin; Braff, Jen; Endy, Drew (2006-03-16)
    We are working to enable the engineering of integrated biological systems. Specifically, we would like to be able to build systems using standard parts that, when combined, have reliable and predictable behavior. Here, ...
  • Design and Evolution of Engineered Biological Systems 
    Kelly, Jason (2005-08-11)
    To date, engineered biological systems have been constructed via a variety of ad hoc approaches. The resulting systems should be thought of as pieces of art. Here, I propose to explore how existing forward engineering ...
  • Design and Evolution of Engineered Biological Systems 
    Kelly, Jason; Michener, Josh; Endy, Drew (Sixth International Conference on Systems Biology, 2005-10-20)
    To date, engineered biological systems have been constructed via a variety of ad hoc approaches. The resulting systems should be thought of as pieces of art. We are interested in exploring how existing forward ...
  • Design of Specific Mammalian Promoters by in silico Prediction 
    Heinemann, Tim; Kramer, Stephen; Velten, Lars; Kranz, Anna-Lena; Bauer, Tobias; Faura, Marti Bernardo; Konig, Rainer; Keienburg, Jens; Eils, Roland; Iwamoto, Nao (2009-10-30)
    The purpose of this RFC is to provide a) a method for the design of rational synthetic promoter sequences based on a statistical analysis about the spatial preference of transcription factor binding sites in human promoter ...
  • Detailed Information Standard 
    Culviner, Peter; Pantalone, Nathaniel; Sagstetter, Mary; Sandock, Sarah; Vrana, Justin; Wu, Yue (2010-12-05)
    The purpose of this standard is to increase the required information that must accompany any parts submitted to the Registry of Standard Biological Parts. This will give users of the parts better assurance of their ...
  • Documentation of BioBrick parts 
    Slomp, Arend; Ekkers, David (2010-12-05)
    Purpose of this RFC is to improve the information supplied by BioBrick part vendors. Reason to have this RFC is that there would be much more information available which can help improve the search time of the user. ...
  • Draft Standard for Biobrick BB-2 Biological Parts 
    Knight, Tom (OpenWetWare, 2008-11-19)
    This standard defines the required sequence properties for a Biobrick(R) BB-2 standard biological part. It does not define any functional characteristics of the parts, nor does it motivate any aspect of these standards.
  • Draft Standard for Biobrick Biological Parts 
    Knight, Tom (OpenWetWare, 2007-05-03)
    This standard defines the required sequence properties for a Biobrick(tm) standard biological part. It does not define any functional characteristics of the parts, nor does it motivate any aspect of these standards. ...
  • DTU Synthetic Promoter Library Standard 
    Fortuna, Patrick; Trolle, Thomas; Borch, Martin Malthe; Haugaard, Anastasiya; Kjaergaard, Maya Friis; Iversen, Lisa Blanc; Jollmann, Annemi; Sander, Anja; Frederiksen, Juliet; Slodkowicz, Grzegorz (2010-12-04)
    The purpose of this RFC is to outline a method for generating a BioBrick compatible Synthetic Promoter Library (SPL) within bacteria in order to fine-tune the expression of BioBrick parts and devices.
  • Engineered Post-Translational Logic (PTL) 
    Sutton, Samantha; Neves, Sara; Leung, Lauren; Endy, Drew (2005-12-07)
    Current synthetic biological circuits make use of protein-DNA and RNA-RNA interactions to control gene expression in bacteria. Systems that rely on the regulation of gene expression are relatively slow and unsuitable for ...
  • Engineering the Interface Between Cellular Chassis and Integrated Biological Systems 
    Canton, Bartholomew (2005-08-08)
    The engineering of biological systems with predictable behavior is a challenging problem. One reason for this difficulty is that engineered biological systems are embedded within complex and variable host cells. To help ...
  • Engineering the Interface Between Cellular Chassis and Integrated Biological Systems 
    Canton, Bartholomew; Endy, Drew (2005-10-21)
    The engineering of biological systems with predictable behavior is a challenging problem. One reason for this difficulty is that engineered biological systems are embedded within complex and variable host cells. To help ...
  • Engineering transcription-based digital logic devices 
    Shetty, Reshma P.; Endy, Drew; Knight, Thomas F. Jr (2007-07-17)
    Implementing in vivo information processing is a key challenge in synthetic biology. We describe the construction and characterization of digital transcription-based devices from zinc fingers and leucine zippers. We also ...
  • Engineering transcription-based digital logic devices 
    Shetty, Reshma P.; Knight, Thomas F. Jr (Sixth International Conference on Systems Biology, 2005-10-20)
    The goal of Synthetic Biology is to engineer systems from biological parts. One class of systems are those whose purpose is to process information. My work seeks to build transcription-based devices for use in combinational ...
  • Fast multiple gene fragment ligation method based on homologous recombination 
    Wang, Ruiyan; Shi, Zhenyu; Li, Teng; Chen, Guoqiang (2010-10-31)
    With the established BioBrick Assembly standards, ligation of different parts has to be accomplished step by step. It can be time-consuming when dealing with multiple fragment ligation. BBF RFC 62 is developed aimed at ...
  • Fast multiple gene fragment ligation method based on Type IIs restriction enzyme DraIII 
    Shi, Zhenyu; Li, Teng; Chen, Guoqiang (2010-10-31)
    With the established BioBrick Assembly standards, ligation of different parts has to be accomplished step by step. It can be time-consuming when dealing with multiple fragment ligation. BBF RFC 61 is developed aimed at ...
  • Fluorescence assay for polymerase arrival rates 
    Che, Austin, 1979- (Massachusetts Institute of Technology, 2004)
    To engineer complex synthetic biological systems will require modular design, assembly, and characterization strategies. The RNA polymerase arrival rate (PAR) is defined to be the rate that RNA polymerases arrive at a ...
  • Fluorescence Assay for Polymerase Arrival Rates 
    Che, Austin (2003-08-31)
    To engineer complex synthetic biological systems will require modular design, assembly, and characterization strategies. The RNA polymerase arrival rate (PAR) is defined to be the rate that RNA polymerases arrive at a ...
  • From Genetically Modified Organisms To Synthetic Biology: Legislation in the European Union, in Six Member Countries and in Switzerland 
    Furger, Franco (2007-12-04)
    This report is based on the assumption that in Europe and in its member countries—with the exception perhaps of Switzerland—“synthetic genomics” as a distinct policy domain does not yet exist. This conclusion is based ...
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