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Browsing Communications by Title

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  • Endy, Drew; Grewal, David; Schultz, Jason; Lynch, Jennifer; Crews, Lee; Fischer, Mark (2010-01-25)
    We present an updated, clean draft for additional public comment of a new legal framework supporting the future of biotechnology. The framework, named here as the BioBrick Public Agreement, is based upon the contribution ...
  • Fischer, Mark; Crews, Lee; Lynch, Jennifer; Schultz, Jason; Grewal, David; Endy, Drew (2009-10-18)
    We present a draft for public comment of a new legal framework supporting the future of biotechnology. The framework, named here as the BioBrick Public Agreement, is based upon the contribution of promises not to assert ...
  • Che, Austin (2004-06-09)
    Construction of complex biological systems can require assembling many modules together. However, existing assembly schemes are lacking in generality, ease of use, or power to perform some desirable operations. Currently, ...
  • Goler, Jonathan A. (2004-05-28)
    The next generations of both biological engineering and computer engineering demand that control be exerted at the molecular level. Creating, characterizing and controlling synthetic biological systems may provide us ...
  • Weiss, Ron, 1970- (Massachusetts Institute of Technology, 2001)
    In this thesis, I present an engineering discipline for obtaining complex, predictable, and reliable cell behaviors by embedding biochemical logic circuits and programmed intercellular communications into cells. To accomplish ...
  • Knight, Thomas F.; Sussman, Gerald Jay (First International Conference on UNCONVENTIONAL MODELS OF COMPUTATION, Auckland, New Zealand, 1998-01-05)
    We propose a biochemically plausible mechanism for constructing digital logic signals and gates of significant complexity within living cells. These mechanisms rely largely on co-opting existing biochemical machinery and ...
  • Knight, Thomas (MIT Artificial Intelligence Laboratory, 2002-05-22)
    This distribution consists of 300 ng aliquots of plasmid DNA for each of twelve components and compound constructs utilizing our idempotent assembly strategy. The dried DNA should be stable at room temperature for many ...
  • Conboy, Caitlin; Braff, Jen; Endy, Drew (2006-03-16)
    We are working to enable the engineering of integrated biological systems. Specifically, we would like to be able to build systems using standard parts that, when combined, have reliable and predictable behavior. Here, ...
  • Kelly, Jason (2005-08-11)
    To date, engineered biological systems have been constructed via a variety of ad hoc approaches. The resulting systems should be thought of as pieces of art. Here, I propose to explore how existing forward engineering ...
  • Kelly, Jason; Michener, Josh; Endy, Drew (Sixth International Conference on Systems Biology, 2005-10-20)
    To date, engineered biological systems have been constructed via a variety of ad hoc approaches. The resulting systems should be thought of as pieces of art. We are interested in exploring how existing forward ...
  • Sutton, Samantha; Neves, Sara; Leung, Lauren; Endy, Drew (2005-12-07)
    Current synthetic biological circuits make use of protein-DNA and RNA-RNA interactions to control gene expression in bacteria. Systems that rely on the regulation of gene expression are relatively slow and unsuitable for ...
  • Canton, Bartholomew; Endy, Drew (2005-10-21)
    The engineering of biological systems with predictable behavior is a challenging problem. One reason for this difficulty is that engineered biological systems are embedded within complex and variable host cells. To help ...
  • Canton, Bartholomew (2005-08-08)
    The engineering of biological systems with predictable behavior is a challenging problem. One reason for this difficulty is that engineered biological systems are embedded within complex and variable host cells. To help ...
  • Shetty, Reshma P.; Endy, Drew; Knight, Thomas F. Jr (2007-07-17)
    Implementing in vivo information processing is a key challenge in synthetic biology. We describe the construction and characterization of digital transcription-based devices from zinc fingers and leucine zippers. We also ...
  • Shetty, Reshma P.; Knight, Thomas F. Jr (Sixth International Conference on Systems Biology, 2005-10-20)
    The goal of Synthetic Biology is to engineer systems from biological parts. One class of systems are those whose purpose is to process information. My work seeks to build transcription-based devices for use in combinational ...
  • Che, Austin (2003-08-31)
    To engineer complex synthetic biological systems will require modular design, assembly, and characterization strategies. The RNA polymerase arrival rate (PAR) is defined to be the rate that RNA polymerases arrive at a ...
  • Che, Austin, 1979- (Massachusetts Institute of Technology, 2004)
    To engineer complex synthetic biological systems will require modular design, assembly, and characterization strategies. The RNA polymerase arrival rate (PAR) is defined to be the rate that RNA polymerases arrive at a ...
  • Furger, Franco (2007-12-04)
    This report is based on the assumption that in Europe and in its member countries—with the exception perhaps of Switzerland—“synthetic genomics” as a distinct policy domain does not yet exist. This conclusion is based ...
  • Anand, Ishan; Kosuri, Sriram; Endy, Drew (2006-05-26)
    Refactoring is a technique used by computer scientists for improving program design. The Endy Laboratory has adapted this process to make the genomes of biological organisms more amenable to human understanding and design ...
  • Knight, Thomas (MIT Artificial Intelligence Laboratory; MIT Synthetic Biology Working Group, 2003)
    The lack of standardization in assembly techniques for DNA sequences forces each DNA assembly reaction to be both an experimental tool for addressing the current research topic, and an experiment in and of itself. One ...
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