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Browsing Communications by Title

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  • Engineered Post-Translational Logic (PTL) 
    Sutton, Samantha; Neves, Sara; Leung, Lauren; Endy, Drew (2005-12-07)
    Current synthetic biological circuits make use of protein-DNA and RNA-RNA interactions to control gene expression in bacteria. Systems that rely on the regulation of gene expression are relatively slow and unsuitable for ...
  • Engineering the Interface Between Cellular Chassis and Integrated Biological Systems 
    Canton, Bartholomew (2005-08-08)
    The engineering of biological systems with predictable behavior is a challenging problem. One reason for this difficulty is that engineered biological systems are embedded within complex and variable host cells. To help ...
  • Engineering the Interface Between Cellular Chassis and Integrated Biological Systems 
    Canton, Bartholomew; Endy, Drew (2005-10-21)
    The engineering of biological systems with predictable behavior is a challenging problem. One reason for this difficulty is that engineered biological systems are embedded within complex and variable host cells. To help ...
  • Engineering transcription-based digital logic devices 
    Shetty, Reshma P.; Endy, Drew; Knight, Thomas F. Jr (2007-07-17)
    Implementing in vivo information processing is a key challenge in synthetic biology. We describe the construction and characterization of digital transcription-based devices from zinc fingers and leucine zippers. We also ...
  • Engineering transcription-based digital logic devices 
    Shetty, Reshma P.; Knight, Thomas F. Jr (Sixth International Conference on Systems Biology, 2005-10-20)
    The goal of Synthetic Biology is to engineer systems from biological parts. One class of systems are those whose purpose is to process information. My work seeks to build transcription-based devices for use in combinational ...
  • Fluorescence Assay for Polymerase Arrival Rates 
    Che, Austin (2003-08-31)
    To engineer complex synthetic biological systems will require modular design, assembly, and characterization strategies. The RNA polymerase arrival rate (PAR) is defined to be the rate that RNA polymerases arrive at a ...
  • Fluorescence assay for polymerase arrival rates 
    Che, Austin, 1979- (Massachusetts Institute of Technology, 2004)
    To engineer complex synthetic biological systems will require modular design, assembly, and characterization strategies. The RNA polymerase arrival rate (PAR) is defined to be the rate that RNA polymerases arrive at a ...
  • From Genetically Modified Organisms To Synthetic Biology: Legislation in the European Union, in Six Member Countries and in Switzerland 
    Furger, Franco (2007-12-04)
    This report is based on the assumption that in Europe and in its member countries—with the exception perhaps of Switzerland—“synthetic genomics” as a distinct policy domain does not yet exist. This conclusion is based ...
  • GeneJax: A Prototype CAD tool in support of Genome Refactoring 
    Anand, Ishan; Kosuri, Sriram; Endy, Drew (2006-05-26)
    Refactoring is a technique used by computer scientists for improving program design. The Endy Laboratory has adapted this process to make the genomes of biological organisms more amenable to human understanding and design ...
  • Idempotent Vector Design for Standard Assembly of Biobricks 
    Knight, Thomas (MIT Artificial Intelligence Laboratory; MIT Synthetic Biology Working Group, 2003)
    The lack of standardization in assembly techniques for DNA sequences forces each DNA assembly reaction to be both an experimental tool for addressing the current research topic, and an experiment in and of itself. One ...
  • iGEM 2005 Invitation Supplement 
    Endy, Drew (2005-09-29)
    This document provides background material in support of the 2005 intercollegiate Genetically Engineered Machine Competition (aka iGEM). Herein, you can read quick summaries of earlier competitions and courses, obtain a ...
  • Impact of Synthetic Genomics on the Threat of Bioterrorism with Viral Agents 
    Collett, Marc (2007-12-04)
    In 2002, a team of researchers at the State University of New York led by Eckard Wimmer assembled a DNA template for the RNA poliovirus using an internet-available nucleotide sequence and mail order synthetic ...
  • The Imperative of Synthetic Biology: A Proposed National Research Initiative 
    Lazowska, Ed; Endy, Drew (2008-12-23)
  • Integrases, Aliens, & Bill Joy 
    Endy, Drew (2013-03-27)
    Research presentation on recent and unpublished work before the MIT Synthetic Biology Working Group on 24 September 2012 in MIT Building 56.
  • In the valley of the shadow of death 
    Brent, Roger (2006-11-22)
    During the 20th century, advances in biological understanding sparked a global revolution in biological capability, or RBC. Since that time, the revolution has proceeded in a Moore's-law-like fashion for many decades. ...
  • May 2006 correspondance between James Randerson and Drew Endy 
    Endy, Drew (2006-06-15)
    I am a science journalist with the Guardian newspaper in London. We are a national daily paper. I am hoping to put together an investigative piece on how easy (or not) it would be for a would-be terrorist to put together ...
  • MONOD, a Collaborative Tool for Manipulating Biological Knowledge 
    Soergel, David; Choi, Kirindi; Thomson, Ty; Doane, Jay; George, Brian; Morgan-Linial, Ross; Brent, Roger; Endy, Drew (2008-06-19)
    We describe an open source software tool called MONOD, for Modeler’s Notebook and Datastore, designed to capture and communicate knowledge generated during the process of building models of many-component biological ...
  • A New Biobrick Assembly Strategy Designed for Facile Protein Engineering 
    Phillips, Ira; Silver, Pamela (2006-04-20)
    The existing biobrick assembly technique[1] provides a straightforward way to combine standardized biological components, termed biobricks. This system, however, is limited in that each protein-encoding biobrick must ...
  • Power and responsibility 
    Brent, Roger (2006-11-21)
    Peter Parker and Uncle Ben are on my mind. The reason is that is that a month ago I was jumped by Craig Venter. There were TV cameras around. The live audience was an interesting, edgy mix, on the interface between ...
  • A Practical Perspective on DNA Synthesis and Biological Security (12/4/2006 Draft) 
    Bügl, Hans; Danner, John; Molinari, Robert; Mulligan, John; Roth, David; Wagner, Ralf; Budowle, Bruce; Scripp, Robert; Smith, Jenifer; Steele, Scott; Church, George; Endy, Drew (2006-12-12)
    Few developments have leapfrogged over predecessor technology as quickly and extensively as synthetic biology. Based on cutting-edge DNA synthesis technology, synthetic biology has already fueled an expansion of ...
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