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Browsing Communications by Title

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  • Thomson, Ty M; Endy, Drew (International Conference on Systems Biology, 2005-10-21)
    The use of traditional tools for the discovery and characterization of biological systems has resulted in a wealth of biological knowledge. Unfortunately, only a small portion of the biological world is well-understood ...
  • Win, Maung Nyan; Smolke, Christina (2009-07-29)
    This supplement provides additional detail on the data analysis methods and the raw data for the RNA devices presented in the published manuscript and supporting online material. The information provided in the current ...
  • Chan, Leon; Kosuri, Sriram; Endy, Drew (2004-10)
    Natural biological systems are selected by evolution to continue to exist. Evolution might give rise to complicated systems that are difficult to discover, measure, model, and direct. Here, we redesign the genome of a ...
  • Vincent Rouilly, Barry Canton; Poul Nielsen, Richard Kitney (2007-10-04)
    One of the main goals in Synthetic Biology is to assess the feasibility of building novel biological systems from interchangeable and standardized parts. In order to collect and share parts, a Registry of standardized DNA ...
  • Fleming, Diane (2007-12-04)
    The ability to synthesize molecules found in living organisms is not new for scientists in the fields of biochemistry and molecular biology. However, the “synthetic biology” made possible by the genetic mapping of ...
  • Sanghvi, Yogesh (2007-12-04)
    Until recently, the synthesis of DNA has been a tedious, time consuming, expensive and experimentally challenging task. But advances in automated instrumentation and improved chemistry have now made it possible to make ...
  • Jones, Robert (2007-12-04)
    Currently the vast majority of DNA synthesis is performed by service companies or by in-house central facilities in universities and large companies. The DNA synthesis industry provides researchers with custom DNA at ...
  • Kosuri, Sriram (2007-02-02)
    Our understanding of why biological systems are designed in a particular way would benefit from biophysically-realistic models that can make accurate predictions on the time-evolution of molecular events given arbitrary ...
  • Arkin, Adam P; Endy, Drew (DARPA White Paper, 1999-10-07)
    One of the hallmarks of biochemical circuits found in nature is analog, asymmetric, asynchronous design. That is, there is little standardization of parts, e.g. all the promoters have different strengths and kinetics, ...
  • Endy, Drew (2003-10)
    Why do biological risks exist? Can we develop and implement a strategy for thoughtfully approaching future biological risks? This short, working report provides an abstract introduction to the problem of biological risk ...
  • Garfinkel, Michele; Endy, Drew; Epstein, Gerald; Friedman, Robert (2007-10-17)
    Gene and genome synthesis, that is, constructing long stretches of DNA from constituent chemicals, provides scientists with new and unparalleled capabilities both for understanding biology and for using it for beneficial ...
  • Baric, Ralph (2007-12-04)
    Viral disease outbreaks have long inspired fear in human populations. Highly pathogenic infectious disease has shaped world history, primarily by impacting the outcome of wars and other global conflicts and precipitating ...
  • Garfinkel, Michele; Endy, Drew; Epstein, Gerald; Friedman, Robert (2007-12-04)
    The following papers were commissioned for the project Synthetic Genomics: Risks and Benefits for Science and Society. These papers formed the basis of many discussions at project workshops and at a large invitational ...
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