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Browsing Communications by Title

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  • Endy, Drew (2007-08-14)
    Biology is a technology for processing information, materials, and energy. As a technology platform, biological systems provide access to artifacts and processes across a range of scales (e.g., the ribosome is a programmable ...
  • Smolke, CD; Win, MN (2009-06-30)
    We are publishing the following draft correction and clarification to Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14283-8. We are now working directly with the PNAS Editor to have this correction published by the ...
  • Wadey, Chuck; Deese, Isadora; Endy, Drew (OpenWetWare & Nature Publishing Group, 2005-11-24)
  • Abelson, Harold; Allen, Don; Coore, Daniel; Hanson, Chris; Homsy, George; Knight, Thomas F., Jr.; Nagpal, Radhika; Rauch, Erik; Sussman, Gerald Jay; Weiss, Ron (1999-08-29)
    Amorphous computing is the development of organizational principles and programming languages for obtaining coherent behaviors from the cooperation of myriads of unreliable parts that are interconnected in unknown, ...
  • Mallet, Alex (2007-02-06)
    I performed computational analyses of various approaches to generating re- engineered versions of the genome of bacteriophage T7. I analyzed a proposed design for a re-engineered genome by examining conservation of T7 ...
  • Shetty, Reshma P (2008-05-27)
    The aim of this thesis is to consider how fundamental engineering principles might best be applied to the design and construction of engineered biological systems. I begin by applying these principles to a key application ...
  • Shetty, Reshma; Lizarazo, Meagan; Rettberg, Randy; Knight, Thomas F., Jr. (Elsevier Inc., 2011-05-20)
    An underlying goal of synthetic biology is to make the process of engineering biological systems easier and more reliable. In support of this goal, we developed BioBrick assembly standard 10 to enable the construction of ...
  • Endy, Drew; Grewal, David; Schultz, Jason; Lynch, Jennifer; Crews, Lee; Fischer, Mark (2010-01-25)
    We present an updated, clean draft for additional public comment of a new legal framework supporting the future of biotechnology. The framework, named here as the BioBrick Public Agreement, is based upon the contribution ...
  • Fischer, Mark; Crews, Lee; Lynch, Jennifer; Schultz, Jason; Grewal, David; Endy, Drew (2009-10-18)
    We present a draft for public comment of a new legal framework supporting the future of biotechnology. The framework, named here as the BioBrick Public Agreement, is based upon the contribution of promises not to assert ...
  • Che, Austin (2004-06-09)
    Construction of complex biological systems can require assembling many modules together. However, existing assembly schemes are lacking in generality, ease of use, or power to perform some desirable operations. Currently, ...
  • Goler, Jonathan A. (2004-05-28)
    The next generations of both biological engineering and computer engineering demand that control be exerted at the molecular level. Creating, characterizing and controlling synthetic biological systems may provide us ...
  • Weiss, Ron, 1970- (Massachusetts Institute of Technology, 2001)
    In this thesis, I present an engineering discipline for obtaining complex, predictable, and reliable cell behaviors by embedding biochemical logic circuits and programmed intercellular communications into cells. To accomplish ...
  • Knight, Thomas F.; Sussman, Gerald Jay (First International Conference on UNCONVENTIONAL MODELS OF COMPUTATION, Auckland, New Zealand, 1998-01-05)
    We propose a biochemically plausible mechanism for constructing digital logic signals and gates of significant complexity within living cells. These mechanisms rely largely on co-opting existing biochemical machinery and ...
  • Knight, Thomas (MIT Artificial Intelligence Laboratory, 2002-05-22)
    This distribution consists of 300 ng aliquots of plasmid DNA for each of twelve components and compound constructs utilizing our idempotent assembly strategy. The dried DNA should be stable at room temperature for many ...
  • Conboy, Caitlin; Braff, Jen; Endy, Drew (2006-03-16)
    We are working to enable the engineering of integrated biological systems. Specifically, we would like to be able to build systems using standard parts that, when combined, have reliable and predictable behavior. Here, ...
  • Kelly, Jason (2005-08-11)
    To date, engineered biological systems have been constructed via a variety of ad hoc approaches. The resulting systems should be thought of as pieces of art. Here, I propose to explore how existing forward engineering ...
  • Kelly, Jason; Michener, Josh; Endy, Drew (Sixth International Conference on Systems Biology, 2005-10-20)
    To date, engineered biological systems have been constructed via a variety of ad hoc approaches. The resulting systems should be thought of as pieces of art. We are interested in exploring how existing forward ...
  • Sutton, Samantha; Neves, Sara; Leung, Lauren; Endy, Drew (2005-12-07)
    Current synthetic biological circuits make use of protein-DNA and RNA-RNA interactions to control gene expression in bacteria. Systems that rely on the regulation of gene expression are relatively slow and unsuitable for ...
  • Canton, Bartholomew (2005-08-08)
    The engineering of biological systems with predictable behavior is a challenging problem. One reason for this difficulty is that engineered biological systems are embedded within complex and variable host cells. To help ...
  • Canton, Bartholomew; Endy, Drew (2005-10-21)
    The engineering of biological systems with predictable behavior is a challenging problem. One reason for this difficulty is that engineered biological systems are embedded within complex and variable host cells. To help ...
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