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Engineering the Interface Between Cellular Chassis and Integrated Biological Systems

Research and Teaching Output of the MIT Community

Show simple item record Canton, Bartholomew 2005-08-08T18:36:16Z 2005-08-08T18:36:16Z 2005-08-08T18:36:16Z
dc.description.abstract The engineering of biological systems with predictable behavior is a challenging problem. One reason for this difficulty is that engineered biological systems are embedded within complex and variable host cells. To help enable the future engineering of biological systems, I will study and optimize the interface between an engineered biological system and its host cell or “chassis”. Other engineering disciplines use modularity to make interacting systems interchangeable and to insulate one system from another. Engineered biological systems are more likely to work as predicted if system function is decoupled from the state of the host cell. Also, specifying and standardizing the interfaces between a system and the chassis will allow systems to be engineered independent of chassis and allow systems to be interchanged between different chassis. To this end, I will build dedicated transcription and translation systems, independent from the equivalent host cell systems. In parallel, I will develop test systems and metrics to measure the interactions between an engineered system and its chassis. Lastly, I will explore methods to “port” a simple engineered system from a prokaryotic to a eukaryotic organism so that the system can function in both organisms. en
dc.format.extent 1323130 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US en
dc.relation.ispartofseries Thesis Proposals en
dc.relation.ispartofseries 1 en
dc.subject Cellular Chassis en
dc.subject Engineered Biological Systems en
dc.title Engineering the Interface Between Cellular Chassis and Integrated Biological Systems en
dc.type Article en
dc.type Working Paper en
dc.type Other en

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